TY - JOUR T1 - Higher alveolar deposition of particulate matter in emphysematous lobes of COPD JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00324-2021 SP - 00324-2021 AU - Nguyen Thanh Tung AU - Shu-Chuan Ho AU - Yueh-Hsun Lu AU - Tzu-Tao Chen AU - Kang-Yun Lee AU - Kuan-Yuan Chen AU - Chih-Da Wu AU - Kian Fan Chung AU - Han-Pin Kuo AU - Huynh Nguyen Xuan Thao AU - Hoang Ba Dung AU - Tran Phan Chung Thuy AU - Sheng-Ming Wu AU - Hsiao-Yun Kou AU - Yueh-Lun Lee AU - Hsiao-Chi Chuang Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/early/2021/07/08/23120541.00324-2021.abstract N2 - Emphysema can be examined quantitatively on high resolution computed tomography (HRCT) by measuring the low-attenuation areas of the lung and has been associated with decrease in lung function in patients with chronic obstructive pulmonary disease (COPD) [1]. Previous studies have associated levels of air pollution with emphysema severity of the total lung [2, 3]. However, the relationship between inhaled particulate matter (PM) deposition in the lungs with the degree of emphysema at the lung lobar level remains poorly understood. We examined the association of lung lobe-deposited doses of PM2.5 (≤2.5 μm) with the extent of emphysema in different lung lobes of COPD subjects.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Nguyen has nothing to disclose.Conflict of interest: Dr. Ho has nothing to disclose.Conflict of interest: Dr. Lu has nothing to disclose.Conflict of interest: Dr. Chen has nothing to disclose.Conflict of interest: Dr. Lee has nothing to disclose.Conflict of interest: Dr. Chen has nothing to disclose.Conflict of interest: Dr. Wu has nothing to disclose.Conflict of interest: Dr. Chung has nothing to disclose.Conflict of interest: Dr. Kuo has nothing to disclose.Conflict of interest: Dr. Huynh has nothing to disclose.Conflict of interest: Dr. Hoang has nothing to disclose.Conflict of interest: Dr. Tran has nothing to disclose.Conflict of interest: Dr. Wu has nothing to disclose.Conflict of interest: Dr. Kou has nothing to disclose.Conflict of interest: Dr. Lee has nothing to disclose.Conflict of interest: Dr. Chuang has nothing to disclose. ER -