TY - JOUR T1 - Impairment of skeletal muscle oxygen extraction and cardiac output are matched in precapillary pulmonary hypertension JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00449-2021 SP - 00449-2021 AU - Harrison Stubbs AU - Colin Church AU - Martin Johnson AU - Stephen Thomson Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/early/2021/07/15/23120541.00449-2021.abstract N2 - Pulmonary arterial hypertension (PAH) is characterised by pathological pulmonary vascular remodelling and increased resistance leading to right heart failure and death [1]. It is thought that exercise intolerance in PAH arises from an impairment in oxygen transport and delivery, driven by a reduced stroke volume [2].FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Harrison Stubbs has nothing to disclose.Conflict of interest: Dr. Colin Church has nothing to disclose.Conflict of interest: Dr. Martin Johnson reports personal fees from Actelion, personal fees from PVRI, personal fees from MSD, outside the submitted work.Conflict of interest: Dr. Stephen Thomson has nothing to disclose. ER -