TY - JOUR T1 - Protein levels, air pollution and vitamin D deficiency: links with allergy JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00237-2021 SP - 00237-2021 AU - Yong Song AU - E. Haydn Walters AU - Michael J. Abramson AU - Gayan Bowatte AU - Dinh S. Bui AU - Jennifer Perret AU - Iain Feather AU - Luke D. Knibbs AU - Richard Wilson AU - David S. Nichols AU - Shyamali C. Dharmage AU - Graeme R. Zosky Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/early/2021/07/22/23120541.00237-2021.abstract N2 - The prevalence of allergic diseases has been increasing for several decades. This has been partly attributed to changing environmental factors such as exposure to traffic-related air pollution (TRAP) and nutrient deficiencies including vitamin D. Furthermore, population-based studies have suggested that air pollution may contribute to vitamin D deficiency [1], while vitamin D levels may modify pollution-driven asthma symptoms in paediatric obesity [2]. Vitamin D supplementation has also been shown to reduce the effects of pollution on asthma and other chronic respiratory diseases [3]. To date, few mechanistic studies have aimed to identify the pathways that may explain these interactions.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Michael J. Abramson holds investigator initiated grants for unrelated research from Pfizer and Boehringer-Ingelheim. He has undertaken an unrelated consultancy for and received assistance with conference travel from Sanofi. He has also received a speaker's fee from GSK. SD holds investigator-initiated grants for unrelated research from GSK.Conflict of interest: Shyamali C. Dharmage received investigator-initiated grants for unrelated research from GSK.Conflict of interest: The other authors declare that they have no relevant conflicts of interest. ER -