TY - JOUR T1 - Exertional multidimensional dyspnoea predicts exacerbation in stable outpatients with COPD JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00150-2021 SP - 00150-2021 AU - Masashi Kanezaki AU - Kunihiko Terada AU - Naoya Tanabe AU - Hiroshi Shima AU - Yoko Hamakawa AU - Susumu Sato Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/early/2021/07/22/23120541.00150-2021.abstract N2 - Dyspnoea is a risk factor for mortality in patients with chronic obstructive pulmonary disease (COPD) [1]. Awareness of the magnitude of respiratory drive to the respiratory muscles contributes to dyspnoea [2]. In line with this mechanism, elevated respiratory neural drive during hospitarisation and at hospital discharge predicts readmission and mortality in patients with acute exacerbation of COPD [3, 4]. Furthermore, patients with COPD who experienced frequent exacerbations had heightened dyspnoea due to hypercapnia, compared with those with infrequent exacerbations [5]. Therefore, changes in the afferent and efferent loops involved in dyspnoea contribute to COPD exacerbations.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Kanezaki has nothing to disclose.Conflict of interest: Kunihiko Terada has no financial conflicts of interest to disclosure concerning the submitted work.Conflict of interest: Dr. TANABE reports grants from FUJIFILM Co., Ltd., outside the submitted work; .Conflict of interest: Dr. Shima has nothing to disclose.Conflict of interest: Dr. Hamakawa has nothing to disclose.Conflict of interest: Dr. Sato reports grants from boehringer ingelheim, Co., Ltd., grants from FUJIFILM Co., Ltd., outside the submitted work. ER -