PT - JOURNAL ARTICLE AU - Ann Roy Febi AU - Mohan K. Manu AU - Aswini Kumar Mohapatra AU - Samir Kumar Praharaj AU - Vasudeva Guddattu TI - Psychological stress and health-related quality of life among tuberculosis patients: a prospective cohort study AID - 10.1183/23120541.00251-2021 DP - 2021 Jul 01 TA - ERJ Open Research PG - 00251-2021 VI - 7 IP - 3 4099 - http://openres.ersjournals.com/content/7/3/00251-2021.short 4100 - http://openres.ersjournals.com/content/7/3/00251-2021.full SO - erjor2021 Jul 01; 7 AB - Economic, social and psychological distress is common in individuals affected by tuberculosis (TB). However, the magnitude of distress, psychological interventions and their effect on the treatment outcomes are often under-evaluated. We examined the level of psychological stress and health-related quality of life (HRQoL) of such patients and the effect of antituberculosis therapy on them. Our prospective cohort study included newly diagnosed adult pulmonary and extrapulmonary TB patients. Assessment of psychological stress was done using the seven-item Generalised Anxiety Disorder questionnaire for anxiety and the nine-item Patient Health Questionnaire for depression. HRQoL was assessed by using the WHOQOL-BREF questionnaire. Of the 86 patients studied, 21 (24.4%) had anxiety symptoms at the baseline, which reduced to 5.8% and 1.2% at 2 months and treatment completion, respectively (p<0.001). Among the subjects, 18 (20.9%) patients had depression, which reduced to 7% and 2.3% at 2 months and treatment completion, respectively (p<0.001). All the mean domain scores of HRQoL were poor at the baseline, which showed improvement at treatment completion (p<0.001). Anxiety and depression were common among TB patients, and there was significant progressive reduction during and after treatment. TB had remarkable negative impacts on HRQoL, with the physical domain being the most affected, and all the domain scores showed significant improvement at treatment completion. Routine screening for depression and anxiety and timely referral to a psychiatrist are required in TB patients to improve the outcome of the disease and quality of life.Tuberculosis patients experience significant psychological stress that can negatively impact their quality of life and warrants proper screening and intervention. https://bit.ly/3jfMEjA