TY - JOUR T1 - Impairment of skeletal muscle oxygen extraction and cardiac output are matched in precapillary pulmonary hypertension JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00449-2021 VL - 7 IS - 3 SP - 00449-2021 AU - Harrison Stubbs AU - Colin Church AU - Martin Johnson AU - Stephen Thomson Y1 - 2021/07/01 UR - http://openres.ersjournals.com/content/7/3/00449-2021.abstract N2 - Pulmonary arterial hypertension (PAH) is characterised by pathological pulmonary vascular remodelling and increased resistance leading to right heart failure and death [1]. It is thought that exercise intolerance in PAH arises from an impairment in oxygen transport and delivery, driven by a reduced stroke volume [2].In precapillary pulmonary hypertension, exercising muscles extract oxygen to a similar level seen in healthy individuals. Exercise limitation is a result of impaired oxygen delivery, which is matched to any impairment in skeletal muscle oxygen extraction. https://bit.ly/3hQUY8m ER -