PT  - JOURNAL ARTICLE
AU  - Dinh S. Bui
AU  - Alvar Agusti
AU  - Haydn Walters
AU  - Caroline Lodge
AU  - Jennifer L. Perret
AU  - Adrian Lowe
AU  - Gayan Bowatte
AU  - Raisa Cassim
AU  - Garun S. Hamilton
AU  - Peter Frith
AU  - Alan James
AU  - Paul S. Thomas
AU  - Debbie Jarvis
AU  - Michael J. Abramson
AU  - Rosa Faner
AU  - Shyamali C. Dharmage
TI  - Lung function trajectory and biomarkers in the Tasmanian Longitudinal Health Study
AID  - 10.1183/23120541.00020-2021
DP  - 2021 Jul 01
TA  - ERJ Open Research
PG  - 00020-2021
VI  - 7
IP  - 3
4099  - http://openres.ersjournals.com/content/7/3/00020-2021.short
4100  - http://openres.ersjournals.com/content/7/3/00020-2021.full
SO  - erjor2021 Jul 01; 7
AB  - Background and objective Different lung function trajectories through life can lead to COPD in adulthood. This study investigated whether circulating levels of biomarkers can differentiate those with accelerated (AD) from normal decline (ND) trajectories.Methods The Tasmanian Longitudinal Health Study (TAHS) is a general population study that measured spirometry and followed up participants from ages 7 to 53 years. Based on their forced expiratory volume in 1 s (FEV1) trajectories from age 7 to 53 years, this analysis included those with COPD at age 53 years (60 with AD and 94 with ND) and controls (n=720) defined as never-smokers with an average FEV1 trajectory. Circulating levels of selected biomarkers determined at 53 and 45 years of age were compared between trajectories.Results Results showed that CC16 levels (an anti-inflammatory protein) were lower and C-reactive protein (CRP) (a pro-inflammatory marker) higher in the AD than in the ND trajectory. Higher CC16 levels were associated with a decreased risk of belonging to the AD trajectory (OR=0.79 (0.63–0.98) per unit increase) relative to ND trajectory. Higher CRP levels were associated with an increased risk of belonging to the AD trajectory (OR=1.07, 95% CI: 1.00–1.13, per unit increase). Levels of CC16 (area under the curve (AUC)=0.69, 95% CI: 0.56–0.81, p=0.002), CRP (AUC=0.63, 95% CI: 0.53–0.72, p=0.01) and the combination of both (AUC=0.72, 95% CI: 0.60–0.83, p<0.001) were able to discriminate between the AD and ND trajectories. Other quantified biomarkers (interleukin (IL)-4, IL-5, IL-6, IL-10 and tumour necrosis factor-α (TNF-α)) were not significantly different between AD, ND and controls.Conclusions Circulating levels of CRP and CC16 measured in late adulthood identify different lung function trajectories (AD versus ND) leading to COPD at age 53 years.In the general population, two circulating biomarkers (CRP and CC16) are associated with different lung function trajectories leading to COPD in adulthood https://bit.ly/3wqWfb3