TY - JOUR T1 - An open-label study of the tolerability and potential efficacy of memantine for treating refractory chronic cough JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00447-2021 VL - 7 IS - 3 SP - 00447-2021 AU - Rayid Abdulqawi AU - Imran Satia AU - Kimberley J. Holt AU - Rachel Dockry AU - Shilpi Sen AU - Jaclyn A. Smith Y1 - 2021/07/01 UR - http://openres.ersjournals.com/content/7/3/00447-2021.abstract N2 - Refractory chronic cough (RCC) is defined as cough lasting longer than 8 weeks either in the absence of an identifiable underlying cause or that remains resistant to treating any potential underlying causes [1]. Affected patients have a poor quality of life and suffer from fatigue, disturbed sleep, incontinence, frustration, anxiety, and depression [2]. Despite being a debilitating condition, no licensed treatment is available.Blocking NMDA receptors with memantine in refractory chronic cough patients is poorly tolerated and demonstrates no improvement in cough https://bit.ly/3kgx2g1 ER -