TY - JOUR T1 - “Changes in health-related quality of life as a marker in the prognosis in COPD patients” JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00181-2021 SP - 00181-2021 AU - Cristóbal Esteban AU - Inmaculada Arostegui AU - Amaia Aramburu AU - Javier Moraza AU - Myriam Aburto AU - Susana Aizpiri AU - Leyre Chasco AU - José M. Quintana Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/early/2021/10/14/23120541.00181-2021.abstract N2 - Chronic obstructive pulmonary disease (COPD) is understood as a complex, heterogeneous and multisystem airway obstructive disease. The association of deterioration in health-related quality of life (HRQoL) with mortality and hospitalisation for COPD exacerbation has been explored in general terms. The specific objectives of this study were to determine whether a change in HRQoL is related over time with mortality and hospitalisation. Overall, 543 patients were recruited through Galdakao Hospital's five outpatient respiratory clinics. Patients were assessed at baseline and the end of the first and second year and were followed-up for 3 years. At each assessment, measurements were made of several variables, including HRQoL using the Saint George's Respiratory Questionnaire (SGRQ). The cohort had moderate obstruction (FEV1 55% of the predicted value). SGRQ total, symptoms, activity and impact scores at baseline were 39.2, 44.5, 48.7 and 32.0, respectively. Every 4-point increase in the SGRQ was associated with an increase in the likelihood of death: “symptoms” domain odds ratio (OR)=1.04; 95% CI (1.00–1.08); “activity” domain OR=1.12; 95% CI (1.08–1.17) and “impacts” domain OR=1.11; 95% CI (1.06–1.15). The rate of hospitalisations per year was 5% (95% CI 3%-8%) to 7% (95% CI 5%-10%) higher for each 4-point increase in the separate domains of the SGRQ. Deterioration in HRQoL by 4 points in SGRQ domain scores over 1 year was associated with an increased likelihood of death and hospitalisation.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Esteban has nothing to disclose.Conflict of interest: Dr. Arostegui has nothing to disclose.Conflict of interest: Dr. Aramburu has nothing to disclose.Conflict of interest: Dr. Moraza has nothing to disclose.Conflict of interest: Dr. Aburto has nothing to disclose.Conflict of interest: Dr. Aizpiri has nothing to disclose.Conflict of interest: Dr. Chasco has nothing to disclose.Conflict of interest: Dr. Quintana has nothing to disclose. ER -