TY - JOUR T1 - The Landscape of Transcriptomics and Proteomics Studies in Sarcoidosis JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00621-2021 SP - 00621-2021 AU - Maneesh Bhargava AU - Shu-Yi Liao AU - Elliott D. Crouser AU - Lisa A. Maier AU - Sonia M. Leach Y1 - 2021/01/01 UR - http://openres.ersjournals.com/content/early/2021/11/18/23120541.00621-2021.abstract N2 - Sarcoidosis is a systemic disease, and the gene/protein expression patterns may be different among different tissues, particularly based on the presence or absence of granulomas and also based on subphenotypes with progressive or non-progressive disease manifestations. There is a growing body of data evaluating global transcriptomic changes across multiple tissue compartments in sarcoidosis. However, whether similar biological pathways are emerging is unknown. Furthermore, the transcriptional impact on the proteome is required to validate molecular pathways driving heterogeneity in sarcoidosis. The purpose of this study is to compare biological inferences from published datasets and explore the compartment specificity of these responses in sarcoidosis. Common pathways identified across datasets or tissue types may serve as convenient biomarkers and could lead to the discovery of novel therapeutic targets.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interests: Dr. Bhargava has nothing to disclose.Conflict of interests: Dr. Liao has nothing to disclose.Conflict of interests: Dr. Crouser has nothing to disclose.Conflict of interests: Dr. Maier has nothing to disclose.Conflict of interests: Dr. Leach has nothing to disclose. ER -