RT Journal Article
SR Electronic
T1 Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00457-2021
DO 10.1183/23120541.00457-2021
VO 7
IS 4
A1 Gang Wang
A1 Jenny Hallberg
A1 Dimitrios Charalampopoulos
A1 Maribel Casas Sanahuja
A1 Robab Breyer-Kohansal
A1 Arnulf Langhammer
A1 Raquel Granell
A1 Judith M. Vonk
A1 Annemiek Mian
A1 Núria Olvera
A1 Lisbeth Mølgaard Laustsen
A1 Eva Rönmark
A1 Alicia Abellan
A1 Alvar Agusti
A1 Syed Hasan Arshad
A1 Anna Bergström
A1 H. Marike Boezen
A1 Marie-Kathrin Breyer
A1 Otto Burghuber
A1 Anneli Clea Bolund
A1 Adnan Custovic
A1 Graham Devereux
A1 Gavin C. Donaldson
A1 Liesbeth Duijts
A1 Ana Esplugues
A1 Rosa Faner
A1 Ferran Ballester
A1 Judith Garcia-Aymerich
A1 Ulrike Gehring
A1 Sadia Haider
A1 Sylvia Hartl
A1 Helena Backman
A1 John W. Holloway
A1 Gerard H. Koppelman
A1 Aitana Lertxundi
A1 Turid Lingaas Holmen
A1 Lesley Lowe
A1 Sara M. Mensink-Bout
A1 Clare S. Murray
A1 Graham Roberts
A1 Linnea Hedman
A1 Vivi Schlünssen
A1 Torben Sigsgaard
A1 Angela Simpson
A1 Jordi Sunyer
A1 Maties Torrent
A1 Stephen Turner
A1 Maarten Van den Berge
A1 Roel C.H. Vermeulen
A1 Sigrid Anna Aalberg Vikjord
A1 Jadwiga A. Wedzicha
A1 Anke H. Maitland van der Zee
A1 Erik Melén
A1 ,
YR 2021
UL http://openres.ersjournals.com/content/7/4/00457-2021.abstract
AB Background The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts.Methods We studied 49 334 participants from 14 population-based cohorts in different age groups (≤10, >10–15, >15–20, >20–25 years, and overall, 5–25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ≥LLN, and FVC z-score <LLN.Results The prevalence of obstructive and restrictive phenotypes varied from 3.2–10.9% and 1.8–7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14–3.04), preterm birth (aOR=1.84, 1.27–2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01–1.35) and family history of asthma (aOR=1.44, 95% CI 1.25–1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5–25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03–1.06 and aOR=0.81, 95% CI 0.78–0.85, per kg·m−2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05–1.46).Conclusion Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.Obstructive and restrictive phenotypes are present from childhood to adulthood but without age trends. Established risk factors for airway disease are associated with the obstructive phenotype, whereas low BMI is associated with the restrictive. https://bit.ly/3BMoMtI