PT - JOURNAL ARTICLE AU - Althobiani, Malik A. AU - Evans, Rebecca A. AU - Alqahtani, Jaber S. AU - Aldhahir, Abdulelah M. AU - Russell, Anne-Marie AU - Hurst, John R. AU - Porter, Joanna C. TI - Home monitoring of physiology and symptoms to detect interstitial lung disease exacerbations and progression: a systematic review AID - 10.1183/23120541.00441-2021 DP - 2021 Oct 01 TA - ERJ Open Research PG - 00441-2021 VI - 7 IP - 4 4099 - https://publications.ersnet.org//content/7/4/00441-2021.short 4100 - https://publications.ersnet.org//content/7/4/00441-2021.full SO - erjor2021 Oct 01; 7 AB - Background Acute exacerbations (AEs) and disease progression in interstitial lung disease (ILD) pose important challenges to clinicians and patients. AEs of ILD are variable in presentation but may result in rapid progression of ILD, respiratory failure and death. However, in many cases AEs of ILD may go unrecognised so that their true impact and response to therapy is unknown. The potential for home monitoring to facilitate early, and accurate, identification of AE and/or ILD progression has gained interest. With increasing evidence available, there is a need for a systematic review on home monitoring of patients with ILD to summarise the existing data. The aim of this review was to systematically evaluate the evidence for use of home monitoring for early detection of exacerbations and/or progression of ILD.Method We searched Ovid-EMBASE, MEDLINE and CINAHL using Medical Subject Headings (MeSH) terms in accordance with the PRISMA guidelines (PROSPERO registration number CRD42020215166).Results 13 studies involving 968 patients have demonstrated that home monitoring is feasible and of potential benefit in patients with ILD. Nine studies reported that mean adherence to home monitoring was >75%, and where spirometry was performed there was a significant correlation (r=0.72–0.98, p<0.001) between home and hospital-based readings. Two studies suggested that home monitoring of forced vital capacity might facilitate detection of progression in idiopathic pulmonary fibrosis.Conclusion Despite the fact that individual studies in this systematic review provide supportive evidence suggesting the feasibility and utility of home monitoring in ILD, further studies are necessary to quantify the potential of home monitoring to detect disease progression and/or AEs.First systematic review that provides supportive evidence for the feasibility and utility of home monitoring in ILD; further studies are necessary to evaluate approaches to detect exacerbation and/or progression https://bit.ly/2Y8OCJL