RT Journal Article SR Electronic T1 Physiotherapy for large airway collapse: an ABC approach JF ERJ Open Research JO erjor FD European Respiratory Society SP 00510-2021 DO 10.1183/23120541.00510-2021 VO 8 IS 1 A1 Grillo, Lizzie J.F. A1 Housley, Georgie M. A1 Gangadharan, Sidhu A1 Majid, Adnan A1 Hull, James H. YR 2022 UL http://openres.ersjournals.com/content/8/1/00510-2021.abstract AB Large airway collapse (LAC) describes the phenomenon of excessive, abnormal, inward movement of the large airways (i.e. trachea and/or main bronchi and/or bronchus intermedius) occurring during the expiratory phase of the respiratory cycle. It is an increasingly well-recognised problem and a prevalent comorbidity in other chronic respiratory conditions (e.g. COPD and asthma). LAC is associated with pervasive respiratory features such as a barking cough, exertional dyspnoea and an increased propensity to lower respiratory tract infection. These symptoms are unpleasant, and patients are often limited in their daily life and their function. The pathophysiology of this condition impairs airway clearance and can cause breathlessness and exercise intolerance, due to a loss of airway patency during expiratory flow. Dysfunctional adaptations to breathing and coughing may further amplify symptoms.This article provides, for the first time, clinically focused physiotherapeutic intervention advice based on our understanding of the pathophysiology of LAC, to support conservative management. It uses the available evidence from LAC, transferable evidence from other conditions and knowledge based on clinical experience. It proposes a practical “ABC model” to ensure physiotherapy assessment and treatments are centred around optimising three key clinical areas: Airways, including airway clearance and cough; Breathing, including breathlessness and breathing pattern; and Capacity for exercise, including an assessment of functional exercise ability.Large airway collapse causes debilitating symptoms of cough, retained secretions, exercise intolerance and breathlessness. This review describes the key role that physiotherapy plays in the conservative management of this condition. https://bit.ly/3pADTUp