TY - JOUR T1 - Vitamin D replacement in children with acute wheeze: a dose-escalation study JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00609-2021 SP - 00609-2021 AU - Christos Stefanidis AU - Andrew Bush AU - Christopher Newby AU - Chinedu Nwokoro AU - Susan Liebeschuetz AU - Imogen p Skene AU - Christopher J Griffiths AU - Adrian R Martineau Y1 - 2022/01/01 UR - http://openres.ersjournals.com/content/early/2022/02/03/23120541.00609-2021.abstract N2 - Meta-analyses report protective effects of vitamin D supplementation against asthma exacerbations and acute respiratory infections in adults [1–3] but data relating to effects of vitamin D on risk of pre-school wheeze and asthma attacks in childhood are more limited [4]. In preparation for a randomised controlled trial (RCT) of vitamin D in children with recurrent preschool wheeze or school-age asthma, we carried out a dose-escalation study to find the daily vitamin D3 supplementation regimen that is most effective in elevating circulating 25-hydroxyvitamin (25[OH]D) concentrations in these children. We hypothesized that daily oral vitamin D3 supplementation of 1,000 IU would be more effective than 400 IU (UK recommendation [5]) in elevating circulating 25(OH)D concentration ≥75 nmol/L at 3 months in vitamin D-insufficient children with recurrent pre-school wheeze or school-age asthma.Current UK recommendation for vitamin D supplementation (400 IU/day) or enhanced supplementation (1000 IU/day) failed to achieve adequate levels of vitamin D (>75 nmol/l) in vitamin D insufficient children with acute wheezeFootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Contributorship statement: Christos Stefanidis (CS), Andrew Bush (AB), Adrian R Martineau (ARM) and Christopher J Griffiths (CG) conceived the study and contributed to study design. CS, AB, ARM, CG, Chinedu Nwokoro (CN), Susan Liebeschuetz (SL) and Imogen Phillipa Skene (IPS) participated in implementation of the study. CS, AB, ARM, CG and Christopher Newby (CN) performed data analysis. CS, AB and ARM wrote the first draft of the article; all other authors critically reviewed it and approved the final version. ER -