TY - JOUR T1 - The landscape of transcriptomic and proteomic studies in sarcoidosis JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00621-2021 VL - 8 IS - 1 SP - 00621-2021 AU - Maneesh Bhargava AU - Shu-Yi Liao AU - Elliott D. Crouser AU - Lisa A. Maier AU - Sonia M. Leach Y1 - 2022/01/01 UR - http://openres.ersjournals.com/content/8/1/00621-2021.abstract N2 - Sarcoidosis is a systemic disease with gene/protein expression patterns that may be different among different tissues, based on the presence or absence of granulomas, and on subphenotypes with progressive or nonprogressive disease manifestations. There is a growing body of data evaluating global transcriptomic changes across multiple tissue compartments in sarcoidosis. However, whether similar biological pathways are involved is unknown. Furthermore, an understanding of the transcriptional impact on the proteome is required to validate molecular pathways driving heterogeneity in sarcoidosis. The purpose of this study was to compare biological inferences from published datasets and explore the compartment specificity of these responses in sarcoidosis. Common pathways identified across datasets or tissue types may serve as convenient biomarkers and could lead to the discovery of novel therapeutic targets.Multiple overlapping pathways are identified in tissue, BAL cells, PBMCs and a sarcoidosis in vitro granuloma model. Inferences from omic studies are constrained by small sample sizes. Studies comparing differences between sarcoidosis phenotypes are needed. https://bit.ly/30NaHz4 ER -