TY - JOUR T1 - Limitations of a 6-minute-walk test to assess the efficacy of menthol for breathlessness JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00090-2022 SP - 00090-2022 AU - Masashi Kanezaki AU - Satoru Ebihara Y1 - 2022/01/01 UR - http://openres.ersjournals.com/content/early/2022/03/17/23120541.00090-2022.abstract N2 - Walking is a vital component of physical activity in patients with chronic obstructive pulmonary disease (COPD). Exertional multidimensional breathlessness in daily life can reduce walking speed and time in patients with established COPD [1]. Improvement in breathlessness beyond a minimal clinically significant difference brought about by pulmonary rehabilitation, pharmaceutical bronchodilators and opioids has been reported [2–4]. However, despite guideline-directed disease-specific therapy, some patients with COPD experience residual breathlessness. Therefore, the application of a novel symptom-based treatment that is widely available will benefit patients with long-term breathlessness.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflicts of interest: None ER -