@article {Satia00119-2022, author = {Imran Satia and Alexandra J. Mayhew and Nazmul Sohel and Om Kurmi and Kieran J. Killian and Paul M. O{\textquoteright}Byrne and Parminder Raina}, title = {Impact of Mental Health and Personality Traits on the Incidence of Chronic Cough in the Canadian Longitudinal Study on Aging (CLSA)}, elocation-id = {00119-2022}, year = {2022}, doi = {10.1183/23120541.00119-2022}, publisher = {European Respiratory Society}, abstract = {Chronic Cough is a common troublesome condition, but risk factors for developing chronic cough are poorly understood. The aim of this study was to understand the relationship between mental health disorders, personality traits and chronic cough.The Canadian Longitudinal Study on Aging is a prospective, nationally generalizable, random sample of adults aged 45{\textendash}85 at baseline recruited between 2011{\textendash}2015 and followed-up 3 years later. Chronic cough was defined a daily cough over the last 12 months. Incidental chronic cough was defined as those participants who reported new-onset chronic cough between baseline and follow-up 1. Current depressive symptoms and psychological distress was assessed using the Center for Epidemiologic Study Short Depression Scale (CESD-10) and Kessler Psychological Distress Scale (K-10) respectively. The {\textquoteleft}Big-Five{\textquoteright} personality traits were assessed using the Ten-Item Personality Inventory (TIPI). Relative risks are reported using a multi-variate mutually adjusted model.At follow-up 1, 2506 participants (11.1\%) reported new-onset chronic cough during the approximate 3-year interval. Depressive symptoms [CESD>=10, RR 1.22(1.03{\textendash}1.44)] and psychological distress [K-10>=22, RR 1.20(1.07{\textendash}1.36)] at baseline were both independent predictors of a higher risk of incidental chronic cough. Prevalent and incidental chronic cough was also independently associated with an increased risk of developing depressive symptoms and psychological distress. Personality traits did not influence the development of chronic cough but did increase the risk of depressive symptoms and psychological distress.This study shows that there is a bi-directional relationship between chronic cough, depressive symptoms and psychological distress and personality traits do not independently influence the development of chronic cough.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Dr. Satia reports grants and personal fees from Merck, during the conduct of the study; grants and personal fees from GSK, personal fees from AstraZeneca, personal fees from Genentech, grants from E. J. Moran Campbell Early Career Award, personal fees from Respiplus, outside the submitted work.Conflict of interest: Dr. Mayhew has nothing to disclose.Conflict of interest: Dr. Nazmul has nothing to disclose.Conflict of interest: Dr. Kurmi has nothing to disclose.Conflict of interest: Dr. Killian has nothing to disclose.Conflict of interest: Dr. O{\textquoteright}Byrne reports grants and personal fees from AstraZeneca, personal fees from GSK, grants from Novartis, grants and personal fees from Medimmune, personal fees from Chiesi, outside the submitted work.Conflict of interest: Dr. Raina has nothing to disclose.}, URL = {https://openres.ersjournals.com/content/early/2022/04/07/23120541.00119-2022}, eprint = {https://openres.ersjournals.com/content/early/2022/04/07/23120541.00119-2022.full.pdf}, journal = {ERJ Open Research} }