RT Journal Article
SR Electronic
T1 Respiratory symptoms and radiological findings in post-acute COVID-19 syndrome
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00479-2021
DO 10.1183/23120541.00479-2021
VO 8
IS 2
A1 Etienne-Marie Jutant
A1 Olivier Meyrignac
A1 Antoine Beurnier
A1 Xavier Jaïs
A1 Tai Pham
A1 Luc Morin
A1 Athénaïs Boucly
A1 Sophie Bulifon
A1 Samy Figueiredo
A1 Anatole Harrois
A1 Mitja Jevnikar
A1 Nicolas Noël
A1 Jérémie Pichon
A1 Anne Roche
A1 Andrei Seferian
A1 Samer Soliman
A1 Jacques Duranteau
A1 Laurent Becquemont
A1 Xavier Monnet
A1 Olivier Sitbon
A1 Marie-France Bellin
A1 Marc Humbert
A1 Laurent Savale
A1 David Montani
A1 ,
YR 2022
UL http://openres.ersjournals.com/content/8/2/00479-2021.abstract
AB Rationale The characteristics of patients with respiratory complaints and/or lung radiologic abnormalities after hospitalisation for coronavirus disease 2019 (COVID-19) are unknown. The objectives were to determine their characteristics and the relationships between dyspnoea, radiologic abnormalities and functional impairment.Methods In the COMEBAC (Consultation Multi-Expertise de Bicêtre Après COVID-19) cohort study, 478 hospital survivors were evaluated by telephone 4 months after hospital discharge, and 177 who had been hospitalised in an intensive care unit (ICU) or presented relevant symptoms underwent an ambulatory evaluation. New-onset dyspnoea and cough were evaluated, and the results of pulmonary function tests and high-resolution computed tomography of the chest were collected.Results Among the 478 patients, 78 (16.3%) reported new-onset dyspnoea, and 23 (4.8%) new-onset cough. The patients with new-onset dyspnoea were younger (56.1±12.3 versus 61.9±16.6 years), had more severe COVID-19 (ICU admission 56.4% versus 24.5%) and more frequent pulmonary embolism (18.0% versus 6.8%) (all p≤0.001) than patients without dyspnoea. Among the patients reassessed at the ambulatory care visit, the prevalence of fibrotic lung lesions was 19.3%, with extent <25% in 97% of the patients. The patients with fibrotic lesions were older (61±11 versus 56±14 years, p=0.03), more frequently managed in an ICU (87.9 versus 47.4%, p<0.001), had lower total lung capacity (74.1±13.7 versus 84.9±14.8% pred, p<0.001) and diffusing capacity of the lung for carbon monoxide (DLCO) (73.3±17.9 versus 89.7±22.8% pred, p<0.001). The combination of new-onset dyspnoea, fibrotic lesions and DLCO <70% pred was observed in eight out of 478 patients.Conclusions New-onset dyspnoea and mild fibrotic lesions were frequent at 4 months, but the association of new-onset dyspnoea, fibrotic lesions and low DLCO was rare.New-onset dyspnoea is a frequent complaint 4 months after #COVID19 and is generally multifactorial, and the combination of new-onset dyspnoea, fibrotic lesions and DLCO <70% pred is rarely observed https://bit.ly/3q4hyyM