RT Journal Article
SR Electronic
T1 Respiratory symptoms and radiological findings in post-acute COVID-19 syndrome
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00479-2021
DO 10.1183/23120541.00479-2021
VO 8
IS 2
A1 Jutant, Etienne-Marie
A1 Meyrignac, Olivier
A1 Beurnier, Antoine
A1 Jaïs, Xavier
A1 Pham, Tai
A1 Morin, Luc
A1 Boucly, Athénaïs
A1 Bulifon, Sophie
A1 Figueiredo, Samy
A1 Harrois, Anatole
A1 Jevnikar, Mitja
A1 Noël, Nicolas
A1 Pichon, Jérémie
A1 Roche, Anne
A1 Seferian, Andrei
A1 Soliman, Samer
A1 Duranteau, Jacques
A1 Becquemont, Laurent
A1 Monnet, Xavier
A1 Sitbon, Olivier
A1 Bellin, Marie-France
A1 Humbert, Marc
A1 Savale, Laurent
A1 Montani, David
A1 ,
YR 2022
UL http://openres.ersjournals.com/content/8/2/00479-2021.abstract
AB Rationale The characteristics of patients with respiratory complaints and/or lung radiologic abnormalities after hospitalisation for coronavirus disease 2019 (COVID-19) are unknown. The objectives were to determine their characteristics and the relationships between dyspnoea, radiologic abnormalities and functional impairment.Methods In the COMEBAC (Consultation Multi-Expertise de Bicêtre Après COVID-19) cohort study, 478 hospital survivors were evaluated by telephone 4 months after hospital discharge, and 177 who had been hospitalised in an intensive care unit (ICU) or presented relevant symptoms underwent an ambulatory evaluation. New-onset dyspnoea and cough were evaluated, and the results of pulmonary function tests and high-resolution computed tomography of the chest were collected.Results Among the 478 patients, 78 (16.3%) reported new-onset dyspnoea, and 23 (4.8%) new-onset cough. The patients with new-onset dyspnoea were younger (56.1±12.3 versus 61.9±16.6 years), had more severe COVID-19 (ICU admission 56.4% versus 24.5%) and more frequent pulmonary embolism (18.0% versus 6.8%) (all p≤0.001) than patients without dyspnoea. Among the patients reassessed at the ambulatory care visit, the prevalence of fibrotic lung lesions was 19.3%, with extent <25% in 97% of the patients. The patients with fibrotic lesions were older (61±11 versus 56±14 years, p=0.03), more frequently managed in an ICU (87.9 versus 47.4%, p<0.001), had lower total lung capacity (74.1±13.7 versus 84.9±14.8% pred, p<0.001) and diffusing capacity of the lung for carbon monoxide (DLCO) (73.3±17.9 versus 89.7±22.8% pred, p<0.001). The combination of new-onset dyspnoea, fibrotic lesions and DLCO <70% pred was observed in eight out of 478 patients.Conclusions New-onset dyspnoea and mild fibrotic lesions were frequent at 4 months, but the association of new-onset dyspnoea, fibrotic lesions and low DLCO was rare.New-onset dyspnoea is a frequent complaint 4 months after #COVID19 and is generally multifactorial, and the combination of new-onset dyspnoea, fibrotic lesions and DLCO <70% pred is rarely observed https://bit.ly/3q4hyyM