RT Journal Article
SR Electronic
T1 Lung volume and density assessment over time in hospitalized COVID-19 patients
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 199
DO 10.1183/23120541.LSC-2022.199
VO 8
IS suppl 8
A1 Vincent Geudens
A1 Jan Van Slambrouck
A1 Gitte Aerts
A1 Lynn Willems
A1 Tinne Goos
A1 Janne Kaes
A1 Iwein Gyselinck
A1 Celine Aelbrecht
A1 Astrid Vermaut
A1 Hanne Beeckmans
A1 Marie Vermant
A1 Charlotte De Fays
A1 Annelore Sacreas
A1 Lucia Aversa
A1 Michaela Orlitova
A1 Arno Vanstapel
A1 John E. Mcdonough
A1 Charles Pilette
A1 Wim Janssens
A1 Wim A. Wuyts
A1 Dirk E. Van Raemdonck
A1 Robin Vos
A1 Ghislaine Gayan-Ramirez
A1 Laurens J. Ceulemans
A1 Bart M. Vanaudenaerde
YR 2022
UL http://openres.ersjournals.com/content/8/suppl_8/199.abstract
AB COVID-19 can have a devastating effect on the lungs, causing acute respiratory distress syndrome (ARDS) which, when not resolved, may progress to pulmonary fibrosis potentially leading to death or transplantation (LTx). We aim to describe the progression of COVID-19 ARDS and fibrosis on lung volume and density over time in vivo and ex vivo using high-resolution computed tomography (HRCT) and µCT.Volume and density of in vivo HRCT scans of 3 COVID-19 patients (P) were assessed over time (P1: 4 scans; P2: 5 scans; P3: 3 scans). After LTx (n=2) or autopsy (n=1) (65.3±26.7 days), explanted right lungs were inflated to total lung capacity, frozen and scanned with whole lung µCT. Lung volumes and density were calculated using Mimics Innovation Suite (Materialise, Belgium). Three discarded donor lungs were used as controls.In vivo lung volume decreased 4 days after symptom onset compared to 1 control and 1 COVID-19 patient before infection, with a steep decline in the first 20 days followed by a more gradual decline. Ex vivo volume of COVID-19 lungs decreased by 60% compared to ex vivo controls (4.2±0.3 vs 1.7±0.5 L; p<0.0058) (fig 1a,b). Volume reduction might be caused by fibroproliferative obliteration of alveolar ducts and spaces as reflected by the increase in density over time (fig 1c).COVID-19 affects lung volume and density rapidly over time, indicating the potential to follow up these parameters to monitor severely ill patients. FootnotesCite this article as ERJ Open Research 2022; 8: Suppl. 8, 199.This article was presented at the 2022 ERS Lung Science Conference, in session “Poster Session 2”.This is an ERS Lung Science Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).