RT Journal Article
SR Electronic
T1 Longitudinal impact of conjugated pneumococcal vaccine (PCV13) on cytokine profile in different asthma phenotypes.
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 226
DO 10.1183/23120541.LSC-2022.226
VO 8
IS suppl 8
A1 Anton, Kostinov
A1 Konishcheva, Anna
YR 2022
UL http://openres.ersjournals.com/content/8/suppl_8/226.abstract
AB Background: Administration of pneumococcal conjugated vaccine (PCV13) has been shown to reduce asthma exacerbation along with related effect on IgG/IgE-Abs to S. pneumoniae. Associated comprehensive related cytokine dynamics in BA endotypes are less clear. We aimed to determine the changes in Th1/Th2/Treg cytokines in 31 patients with different BA endotypes after PCV13 immunization.Methods: ELISA level of IL-4, IL-6, IL-8, IL-10, IL-18, IFN-g, TNF-, MCP-1 measured in serum samples initially, 6 weeks, 6 and 12 months after vaccination. ACT –test and spirometric values have been measured at the same points.Results: Under clustering of inflammatory BA phenotypes an increase in IFN-g (p<0,05) – up to 1,96 pg/ml [0,00; 2,6]was observed in allergic (Th2) BA 6 weeks from PCV13 administration. On the contrary, in patients with non-Th2 endotype, and asthma with obesity, lower values of IFN-g after 6 weeks (0,00 [0,00; 0,00], (p<0,05)) and 6 months (0,00 [0,00; 0.00], (p<0,05))have been detected. For late-onset Th2 asthma significant increase on IL-10 was observed after 12 months (3,12 [1,00; 8,22]) along with reduced serum IL-6 relative to other patients with late-onset non-Th2 asthma 6 months after vaccination (0,87 [0,66; 0,95](p<0,05).Conclusion: Beneficial changes in proinflammatory/regulatory cytokines along with clinical effect are dependent from asthma phenotype and stable after 12 months from PCV13 administration especially in late-onset non-Th2 asthma indicating its immunomodulatory potential for further therapeutic strategies.FootnotesCite this article as ERJ Open Research 2022; 8: Suppl. 8, 226.This article was presented at the 2022 ERS Lung Science Conference, in session “Poster Session 2”.This is an ERS Lung Science Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).