@article {Moermans169, author = {Catherine Moermans and Sophie Graff and Medard Laurie and Schleich Florence and Virginie Paulus and Fran{\c c}oise Guissard and Monique Henket and Renaud Louis}, title = {Effects of probiotics in uncontrolled asthma}, volume = {8}, number = {suppl 8}, elocation-id = {169}, year = {2022}, doi = {10.1183/23120541.LSC-2022.169}, publisher = {European Respiratory Society}, abstract = {Introduction: Refractory asthma still represents a certain percentage of asthmatic patients despite the use of high medication. There is a need for new therapeutics allowing a better asthma control. Probiotics are able to modulate the intestinal microbiota homeostasis as well as the immune system, to moderate inflammation and appeared to be very well tolerated and safe.Goal: The goal of this study was to assess if probiotics have a beneficial impact on refractory asthma.Methods: The randomized double blind placebo control study was performed at the CHU of Liege (Clinicaltrial.org ID: NCT03341403). Fifty-five uncontrolled asthmatics patients were included. Patients received the dietary Supplement Synbiotic {\textquotedblleft}Probiotical{\textregistered}/Bactecal{\textregistered}{\textquotedblright} 3 pills a day or a placebo during 3 months. Patients were evaluated before and 1-3-6 months for the lung function, the exhaled nitric oxide value, the inflammatory blood and sputum profiles and the quality of life and asthma control assessed by questionnaires: asthma control test (ACT), asthma control questionnaire (ACQ), asthma quality of life questionnaire (AQLQ ). This study was approved by the Ethics committee of CHU Liege (2017/248) and all subjects gave written informed consent for participation.Results: The ACQ and AQLQ scores improved significantly in the probiotic group at 3 months which was not the case in the placebo group. Also, the FEV1/FVC post bronchodilation improved at 3 months compared to baseline in the probiotic group only. Finally, the IgE, fibrinogen and neutrophils blood levels decreased at 1 month after probiotics.Conclusions: Probiotics may have a valuable impact in refractory asthma. These promising results need to be validated in a larger population of asthmatic patients.FootnotesCite this article as ERJ Open Research 2022; 8: Suppl. 8, 169.This article was presented at the 2022 ERS Lung Science Conference, in session {\textquotedblleft}Poster Session 2{\textquotedblright}.This is an ERS Lung Science Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).}, URL = {https://openres.ersjournals.com/content/8/suppl_8/169}, eprint = {https://openres.ersjournals.com/content}, journal = {ERJ Open Research} }