PT  - JOURNAL ARTICLE
AU  - Wang, Lei
AU  - Pelgrim, Charlotte E.
AU  - Peralta Marzal, Lucía N.
AU  - Korver, Stephanie
AU  - Van Ark, Ingrid
AU  - Leusink-Muis, Thea
AU  - Van Helvoort, Ardy
AU  - Keshavarzian, Ali
AU  - Kraneveld, Aletta D.
AU  - Garssen, Johan
AU  - Henricks, P.A.J.
AU  - Folkerts, Gert
AU  - Braber, Saskia
TI  - Mucosal immunology of the gut and lung in a cigarette smoke-induced murine model for COPD: the lung-gut axis
AID  - 10.1183/23120541.LSC-2022.53
DP  - 2022 Mar 10
TA  - ERJ Open Research
PG  - 53
VI  - 8
IP  - suppl 8
4099  - https://publications.ersnet.org//content/8/suppl_8/53.short
4100  - https://publications.ersnet.org//content/8/suppl_8/53.full
SO  - erjor2022 Mar 10; 8
AB  - Introduction: Chronic obstructive pulmonary disease (COPD) is often associated with intestinal comorbidities, which considerably influence disease prognosis and clinical outcomes. However, the involvement of the gut, as well as the cross-talk between the gut and lung, in the immuno-pathophysiology of COPD has hardly been investigated.Aim: In this study, changes in intestinal homeostasis and immunity in a cigarette smoke-induced murine model for COPD have been investigated.Methods: Mice were exposed to cigarette smoke or air for 72 days. The pathophysiology of the lungs and small intestine, systemic inflammation as well as the intestinal immune network for IgA production were investigated.Results: Cigarette smoke exposure increased the airway inflammatory cell numbers, mucus production, and different inflammatory mediators in bronchoalveolar lavage fluid and serum, T helper1 cells were enhanced in the spleen. Histomorphological changes were observed in the proximal small intestine after cigarette smoke exposure, and the intestinal immune network for IgA production as measured by transcriptome sequencing in the distal small intestine associated with increased fecal sIgA levels and enlargement of Peyer’s patches.Conclusion: Cigarette smoke exposure affects intestinal health as observed by changes in intestinal histomorphology and immune network for IgA production. Elevated systemic mediators might play a role in cigarette smoke-induced lung-gut crosstalk. These current findings contribute to a better understanding of intestinal disorders in COPD, which is essential for the interpretation of co-morbidities and therapeutic opportunities.FootnotesCite this article as ERJ Open Research 2022; 8: Suppl. 8, 53.This article was presented at the 2022 ERS Lung Science Conference, in session “Poster Session 2”.This is an ERS Lung Science Conference abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).