TY - JOUR T1 - High flow nasal cannula oxygen therapy: P-SILI or not P-SILI? JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00203-2022 SP - 00203-2022 AU - Elise Artaud-Macari AU - Christophe Girault Y1 - 2022/01/01 UR - http://openres.ersjournals.com/content/early/2022/05/05/23120541.00203-2022.abstract N2 - During hypoxemic acute respiratory failure (ARF), compared to facemask at 12 L·min−1, HFNC set at 40 L·min−1 has been shown not only to increase end-expiratory lung volumes (EELV) but also improve ventilation distribution and homogeneity, dynamic lung compliance and transpulmonary driving pressure [4]. A linear relationship has been shown between increase flow and EELV of dependent lung regions, whereas this relationship did not exist for non-dependent lung regions, without any evidence of increased tidal volume [5]. Basile et al. [6], using HFNC at 100 L·min−1, have confirmed the correlation between flow and EELV as well as with the homogeneity of lung volume distribution.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article. ER -