RT Journal Article
SR Electronic
T1 Pulmonary function test and computed tomography features during follow-up after SARS, MERS and COVID-19: a systematic review and meta-analysis
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00056-2022
DO 10.1183/23120541.00056-2022
VO 8
IS 2
A1 Christopher C. Huntley
A1 Ketan Patel
A1 Shahnoor-E-Salam Bil Bushra
A1 Farah Mobeen
A1 Michael N. Armitage
A1 Anita Pye
A1 Chloe B. Knight
A1 Alyaa Mostafa
A1 Marie Kershaw
A1 Aishah Z. Mughal
A1 Emily McKemey
A1 Alice M. Turner
A1 P. Sherwood Burge
A1 Gareth I. Walters
YR 2022
UL http://openres.ersjournals.com/content/8/2/00056-2022.abstract
AB Background The COVID-19 pandemic follows severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus epidemics. Some survivors of COVID-19 infection experience persistent respiratory symptoms, yet their cause and natural history remain unclear. Follow-up after SARS and MERS may provide a model for predicting the long-term pulmonary consequences of COVID-19.Methods This systematic review and meta-analysis aims to describe and compare the longitudinal pulmonary function test (PFT) and computed tomography (CT) features of patients recovering from SARS, MERS and COVID-19. Meta-analysis of PFT parameters (DerSimonian and Laird random-effects model) and proportion of CT features (Freeman-Tukey transformation random-effects model) were performed.Findings Persistent reduction in the diffusing capacity for carbon monoxide following SARS and COVID-19 infection is seen at 6 months follow-up, and 12 months after MERS. Other PFT parameters recover in this time. 6 months after SARS and COVID-19, ground-glass opacity, linear opacities and reticulation persist in over 30% of patients; honeycombing and traction dilatation are reported less often. Severe/critical COVID-19 infection leads to greater CT and PFT abnormality compared to mild/moderate infection.Interpretation Persistent diffusion defects suggestive of parenchymal lung injury occur after SARS, MERS and COVID-19 infection, but improve over time. After COVID-19 infection, CT features are suggestive of persistent parenchymal lung injury, in keeping with a post-COVID-19 interstitial lung syndrome. It is yet to be determined if this is a regressive or progressive disease.A mild reduction in DLCO, and ground-glass opacity, linear opacities and reticulation on CT may persist after #COVID19 at 6 months: severe/critical COVID-19 acute infection increases this risk. Similar patterns observed after SARS and MERS. https://bit.ly/35u3ree