PT  - JOURNAL ARTICLE
AU  - Nigel S. Cook
AU  - Gerard J. Criner
AU  - Pierre-Régis Burgel
AU  - Katie Mycock
AU  - Tom Gardner
AU  - Phil Mellor
AU  - Pam Hallworth
AU  - Kate Sully
AU  - Sophi Tatlock
AU  - Beyza Klein
AU  - Byron Jones
AU  - Olivier Le Rouzic
AU  - Kip Adams
AU  - Kirsten Phillips
AU  - Mike McKevitt
AU  - Kazuko Toyama
AU  - Florian S. Gutzwiller
TI  - People living with moderate-to-severe COPD prefer improvement of daily symptoms over the improvement of exacerbations: a multicountry patient preference study
AID  - 10.1183/23120541.00686-2021
DP  - 2022 Apr 01
TA  - ERJ Open Research
PG  - 00686-2021
VI  - 8
IP  - 2
4099  - http://openres.ersjournals.com/content/8/2/00686-2021.short
4100  - http://openres.ersjournals.com/content/8/2/00686-2021.full
SO  - erjor2022 Apr 01; 8
AB  - Introduction This patient preference study sought to quantify the preferences of people living with COPD regarding symptom improvement in the UK, USA, France, Australia and Japan.Methods The inclusion criteria were people living with COPD aged 40 years or older who experienced ≥1 exacerbation in the previous year with daily symptoms of cough and excess mucus production. The study design included: 1) development of an attributes and levels grid through qualitative patient interviews; and 2) implementation of the main online quantitative survey, which included a discrete choice experiment (DCE) to allow assessment of attributes and levels using hypothetical health state profiles. Preference weights (utilities) were derived from the DCE using hierarchical Bayesian analysis. A preference simulator was developed that enabled different health state scenarios to be evaluated based on the predicted patient preferences.Results 1050 people living with moderate-to-severe COPD completed the survey. All attributes were considered important when patients determined their preferences in the DCE. In a health state preference simulation, two hypothetical health states (comprising attribute levels) with qualitatively equivalent improvements in A) cough and mucus and B) shortness of breath (SOB) resulted in a clear preference for cough and mucus improved profile. When comparing two profiles with C) daily symptoms improved and D) exacerbations improved, there was a clear preference for the daily symptoms improved profile.Conclusions People living with moderate-to-severe COPD prefer to reduce cough and mucus production together over improvement of SOB and would prefer to reduce combined daily symptoms over an improvement in exacerbations.There is a need for symptom-focused therapies to deliver meaningful outcomes for people living with COPD https://bit.ly/3KqcSur