RT Journal Article
SR Electronic
T1 People living with moderate-to-severe COPD prefer improvement of daily symptoms over the improvement of exacerbations: a multicountry patient preference study
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00686-2021
DO 10.1183/23120541.00686-2021
VO 8
IS 2
A1 Nigel S. Cook
A1 Gerard J. Criner
A1 Pierre-Régis Burgel
A1 Katie Mycock
A1 Tom Gardner
A1 Phil Mellor
A1 Pam Hallworth
A1 Kate Sully
A1 Sophi Tatlock
A1 Beyza Klein
A1 Byron Jones
A1 Olivier Le Rouzic
A1 Kip Adams
A1 Kirsten Phillips
A1 Mike McKevitt
A1 Kazuko Toyama
A1 Florian S. Gutzwiller
YR 2022
UL http://openres.ersjournals.com/content/8/2/00686-2021.abstract
AB Introduction This patient preference study sought to quantify the preferences of people living with COPD regarding symptom improvement in the UK, USA, France, Australia and Japan.Methods The inclusion criteria were people living with COPD aged 40 years or older who experienced ≥1 exacerbation in the previous year with daily symptoms of cough and excess mucus production. The study design included: 1) development of an attributes and levels grid through qualitative patient interviews; and 2) implementation of the main online quantitative survey, which included a discrete choice experiment (DCE) to allow assessment of attributes and levels using hypothetical health state profiles. Preference weights (utilities) were derived from the DCE using hierarchical Bayesian analysis. A preference simulator was developed that enabled different health state scenarios to be evaluated based on the predicted patient preferences.Results 1050 people living with moderate-to-severe COPD completed the survey. All attributes were considered important when patients determined their preferences in the DCE. In a health state preference simulation, two hypothetical health states (comprising attribute levels) with qualitatively equivalent improvements in A) cough and mucus and B) shortness of breath (SOB) resulted in a clear preference for cough and mucus improved profile. When comparing two profiles with C) daily symptoms improved and D) exacerbations improved, there was a clear preference for the daily symptoms improved profile.Conclusions People living with moderate-to-severe COPD prefer to reduce cough and mucus production together over improvement of SOB and would prefer to reduce combined daily symptoms over an improvement in exacerbations.There is a need for symptom-focused therapies to deliver meaningful outcomes for people living with COPD https://bit.ly/3KqcSur