PT - JOURNAL ARTICLE AU - Juliane Nascimento de Mattos AU - Carlos Eugênio Santiago Escovar AU - Manuela Zereu AU - Adalberto Sperb Rubin AU - Spencer Marcantonio Camargo AU - Tan-Lucien Mohammed AU - Ricardo Sales dos Santos AU - Nupur Verma AU - Diana Penha Pereira AU - Erique Guedes Pinto AU - Tiago Machuca AU - Tássia Machado Medeiros AU - Bruno Hochhegger TI - Computed tomography on lung cancer screening is useful for adjuvant comorbidity diagnosis in developing countries AID - 10.1183/23120541.00061-2022 DP - 2022 Apr 01 TA - ERJ Open Research PG - 00061-2022 VI - 8 IP - 2 4099 - http://openres.ersjournals.com/content/8/2/00061-2022.short 4100 - http://openres.ersjournals.com/content/8/2/00061-2022.full SO - erjor2022 Apr 01; 8 AB - Purpose The aim of this study was to analyse and quantify the prevalence of six comorbidities from lung cancer screening (LCS) on computed tomography (CT) scans of patients from developing countries.Methods For this retrospective study, low-dose CT scans (n=775) were examined from patients who underwent LCS in a tertiary hospital between 2016 and 2020. An age- and sex-matched control group was obtained for comparison (n=370). Using the software, coronary artery calcification (CAC), the skeletal muscle area, interstitial lung abnormalities, emphysema, osteoporosis and hepatic steatosis were accessed. Clinical characteristics of each participant were identified. A t-test and Chi-squared test were used to examine differences between these values. Interclass correlation coefficients (ICCs) and interobserver agreement (assessed by calculating kappa coefficients) were calculated to assess the correlation of measures interpreted by two observers. p-values <0.05 were considered significant.Results One or more comorbidities were identified in 86.6% of the patients and in 40% of the controls. The most prevalent comorbidity was osteoporosis, present in 44.2% of patients and in 24.8% of controls. New diagnoses of cardiovascular disease, emphysema and osteoporosis were made in 25%, 7% and 46% of cases, respectively. The kappa coefficient for CAC was 0.906 (p<0.001). ICCs for measures of liver, spleen and bone density were 0.88, 0.93 and 0.96, respectively (p<0.001).Conclusions CT data acquired during LCS led to the identification of previously undiagnosed comorbidities. The LCS is useful to facilitate comorbidity diagnosis in developing countries, providing opportunities for its prevention and treatment.Lung cancer screening is useful to facilitate comorbidity diagnosis in developing countries, providing opportunities for its prevention and treatment https://bit.ly/3KEdGuW