RT Journal Article
SR Electronic
T1 Computed tomography on lung cancer screening is useful for adjuvant comorbidity diagnosis in developing countries
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00061-2022
DO 10.1183/23120541.00061-2022
VO 8
IS 2
A1 Juliane Nascimento de Mattos
A1 Carlos Eugênio Santiago Escovar
A1 Manuela Zereu
A1 Adalberto Sperb Rubin
A1 Spencer Marcantonio Camargo
A1 Tan-Lucien Mohammed
A1 Ricardo Sales dos Santos
A1 Nupur Verma
A1 Diana Penha Pereira
A1 Erique Guedes Pinto
A1 Tiago Machuca
A1 Tássia Machado Medeiros
A1 Bruno Hochhegger
YR 2022
UL http://openres.ersjournals.com/content/8/2/00061-2022.abstract
AB Purpose The aim of this study was to analyse and quantify the prevalence of six comorbidities from lung cancer screening (LCS) on computed tomography (CT) scans of patients from developing countries.Methods For this retrospective study, low-dose CT scans (n=775) were examined from patients who underwent LCS in a tertiary hospital between 2016 and 2020. An age- and sex-matched control group was obtained for comparison (n=370). Using the software, coronary artery calcification (CAC), the skeletal muscle area, interstitial lung abnormalities, emphysema, osteoporosis and hepatic steatosis were accessed. Clinical characteristics of each participant were identified. A t-test and Chi-squared test were used to examine differences between these values. Interclass correlation coefficients (ICCs) and interobserver agreement (assessed by calculating kappa coefficients) were calculated to assess the correlation of measures interpreted by two observers. p-values <0.05 were considered significant.Results One or more comorbidities were identified in 86.6% of the patients and in 40% of the controls. The most prevalent comorbidity was osteoporosis, present in 44.2% of patients and in 24.8% of controls. New diagnoses of cardiovascular disease, emphysema and osteoporosis were made in 25%, 7% and 46% of cases, respectively. The kappa coefficient for CAC was 0.906 (p<0.001). ICCs for measures of liver, spleen and bone density were 0.88, 0.93 and 0.96, respectively (p<0.001).Conclusions CT data acquired during LCS led to the identification of previously undiagnosed comorbidities. The LCS is useful to facilitate comorbidity diagnosis in developing countries, providing opportunities for its prevention and treatment.Lung cancer screening is useful to facilitate comorbidity diagnosis in developing countries, providing opportunities for its prevention and treatment https://bit.ly/3KEdGuW