RT Journal Article
SR Electronic
T1 52-year follow-up of a birth cohort reveals a high pneumonia incidence among young men
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00707-2021
DO 10.1183/23120541.00707-2021
VO 8
IS 2
A1 Pia Holma
A1 Paula Pesonen
A1 Olli Mustonen
A1 Marjo-Riitta Järvelin
A1 Heikki Kauma
A1 Juha Auvinen
A1 Timo Hautala
YR 2022
UL http://openres.ersjournals.com/content/8/2/00707-2021.abstract
AB Background Knowledge of pneumonia incidence and risk factors in adults is mainly based on clinical studies of selected patient data and registers with ageing populations. Prospective population-based investigations, such as birth cohort studies, are needed to understand pneumonia incidence and risk factors among young and working-age populations.Methods Northern Finland Birth Cohort (NFBC) 1966 data (n=6750) were analysed for pneumonia incidence and risk factors. Incidence analysis was replicated using data from an independent NFBC 1986 cohort (n=9207). Pneumonia in relation to chronic conditions and lifestyle factors was analysed.Results A peak with a maximum of 227 pneumonia episodes per 10 000 among men between the ages of 19 and 21 years was found in two independent cohorts. Pneumonia was associated with male sex (relative risk 1.72, 95% CI 1.45–2.04; p<0.001), low educational level (relative risk 2.30, 95% CI 1.72–3.09; p<0.001), smoking (relative risk 1.55, 95% CI 1.31–1.84; p<0.001), asthma (relative risk 2.19, 95% CI 1.73–2.75; p<0.001), cardiovascular diseases (relative risk 2.50, 95% CI 2.04–3.07; p=0.001), kidney diseases (relative risk 4.14, 95% CI 2.81–6.10; p<0.001), rheumatoid arthritis (relative risk 2.69, 95% CI 1.80–4.01; p<0.001), psoriasis (relative risk 2.91, 95% CI 1.92–4.41; p<0.001) and type II diabetes (relative risk 1.80, 95% CI 1.34–2.42; p<0.001). Men with excessive alcohol consumption at age 31 years were at risk of future pneumonia (relative risk 2.40, 95% CI 1.58–3.64; p<0.001).Conclusions Birth cohort data can reveal novel high-risk subpopulations, such as young males. Our study provides understanding of pneumonia incidence and risk factors among young and working age populations.This prospective follow-up of Northern Finland Birth Cohorts up to 52 years shows a high peak in pneumonia incidence among young male adults, and reveals pneumonia risk factors among the young and working-age populations https://bit.ly/38S0tkZ