%0 Journal Article %A Hrefna Katrín Gudmundsdóttir %A Oda C. L. Carlsen %A Karen Eline Stensby Bains %A Martin Färdig %A Guttorm Haugen %A Christine M. Jonassen %A Marissa LeBlanc %A Björn Nordlund %A Eva Maria Rehbinder %A Håvard O. Skjerven %A Anne Cathrine Staff %A Riyas Vettukattil %A Karin C. Lødrup Carlsen %T Infant lung function and maternal physical activity in the first half of pregnancy %D 2022 %R 10.1183/23120541.00172-2022 %J ERJ Open Research %P 00172-2022 %X Background and aim : Physical activity (PA) in pregnancy is important for maternal and possibly offspring's health. To study early origins of lung function we aimed to determine whether PA in the first half of pregnancy was associated with lung function in healthy three-month-old infants.Methods : From the general population-based PreventADALL birth cohort recruiting infants antenatally in Norway and Sweden, all 812 infants (48.8% girls) with available tidal flow-volume measures in the awake state at three months of age and mid-pregnancy data on PA were included. PA was self-reported by the mothers, and based on intensity we categorised them as active or inactive during pregnancy. Further we defined active mothers as fairly or highly active. The main outcome was a ratio of time to Peak Tidal Expiratory Flow to Expiratory time (tPTEF/tE)<0.25. Associations were analysed by logistic regression, adjusting for maternal age, education, parity, pre-pregnancy body mass index, in-utero nicotine exposure and parental atopy.Results : The mean (sd) tPTEF/tE was 0.391 (0.08) and did not differ significantly according to maternal PA level in pregnancy. The 290 infants of inactive mothers had higher odds of having tPTEF/tE<0.25 compared to infants of all active mothers (OR 2.07, 95% CI [1.13, 3.82], p=0.019) and compared to infants (n=224) of fairly active (OR 2.83, 95% CI [1.26, 7.24], p=0.018) but not highly active mothers (n=298).Conclusion : Based on self-reported maternal PA in the first half of pregnancy, three-month-old infants of inactive compared to active mothers had higher odds of a low tPTEF/tE.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: The authors have no conflicts of interest to disclose. %U https://openres.ersjournals.com/content/erjor/early/2022/07/19/23120541.00172-2022.full.pdf