PT - JOURNAL ARTICLE AU - Keen, Carol AU - Smith, Ian AU - Hashmi-Greenwood, Molly AU - Sage, Karen AU - Kiely, David G TI - Pulmonary hypERtension and measurement of exerciSe caPacIty REmotely: evaluation of the 1-minute sit to stand test (PERSPIRE): a cohort study AID - 10.1183/23120541.00295-2022 DP - 2022 Jan 01 TA - ERJ Open Research PG - 00295-2022 4099 - http://openres.ersjournals.com/content/early/2022/08/11/23120541.00295-2022.short 4100 - http://openres.ersjournals.com/content/early/2022/08/11/23120541.00295-2022.full AB - Background Multi-parameter risk assessment is recommended to aid treatment decisions in patients with pulmonary arterial hypertension. The 1-minute sit-to-stand test has been validated for use in other respiratory illnesses. The aim of this study was to evaluate its safety in the hospital setting and potential utility in remote assessment in patients with pulmonary hypertension.Methods In a prospective cohort study design patients performed the 1-minute sit-to-stand and Incremental Shuttle Walk tests on the same day. The primary aim of the study was to assess safety signals and correlations with other metrics used in risk assessment.Results Sixty patients with pulmonary arterial hypertension and 15 with chronic thromboembolic pulmonary hypertension were enrolled. No adverse events were recorded. Post-test change in physiological parameters was lower for the 1-minute sit-to-stand than for the Incremental Shuttle Walk test in heart rate (+9.4(8.0)bpm versus +38.3(25.9)bpm (p<0.001)), oxygen saturation (−3.8(4.0)% versus −8.9(7.3)%, (p<0.01)) and systolic blood pressure (+10.1(10.5)mmHg versus +17.7(19)mmHg, p<0.001). There were significant correlations between the 1-minute-sit-to-stand and Incremental Shuttle Walking test (r= 0.702, p< 0.01), WHO FC (−0.449, p<0.01), emPHAsis-10 (−0.436, p<0.001) and NT-proBNP (−0.270, p=0.022). Ninety-seven percent of patients were willing to perform the test at home.Conclusion This study has demonstrated the safety, sub-maximal characteristics of the 1-minute sit-to-stand test in pulmonary arterial hypertension chronic thromboembolic pulmonary hypertension in the hospital setting, its positive correlation with the Incremental Shuttle Walk test and potential role in remote risk assessment. Further evaluation of this exercise test is now warranted.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.