RT Journal Article
SR Electronic
T1 Complete response to anti-interleukin-5 biologics in a real-life setting: results from the nationwide Danish Severe Asthma Register
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00238-2022
DO 10.1183/23120541.00238-2022
VO 8
IS 4
A1 Marianne Baastrup Soendergaard
A1 Susanne Hansen
A1 Anne-Sofie Bjerrum
A1 Ole Hilberg
A1 Sofie Lock-Johansson
A1 Kjell Erik Julius Håkansson
A1 Truls Sylvan Ingebrigtsen
A1 Claus Rikard Johnsen
A1 Linda Makowska Rasmussen
A1 Anna von Bülow
A1 Karin Dahl Assing
A1 Johannes Martin Schmid
A1 Charlotte Suppli Ulrik
A1 Celeste Porsbjerg
YR 2022
UL http://openres.ersjournals.com/content/8/4/00238-2022.abstract
AB Background Phase III regulatory trials show that anti-interleukin (IL)-5 biologics efficiently reduce exacerbations and the use of maintenance oral corticosteroids (mOCS) in patients with severe eosinophilic asthma. However, patients eligible for these trials differ significantly compared with real-life severe asthma populations. Therefore, our aim was to explore efficacy in a real-life setting. The Danish Severe Asthma Register (DSAR) is a complete, nationwide register that comprises all Danish patients on biological therapy for severe asthma.Methods This prospective study identified patients in the DSAR who were complete responders to anti-IL-5 biologics after 1 year of treatment. A complete response was defined as resolution of the parameter setting the indication, i.e. recurrent exacerbations and/or use of mOCS.Results A total of 289 out of 502 (58%) patients were complete responders to anti-IL-5 biologics after 12 months. Complete responders had greater improvements in forced expiratory volume in 1 s and Asthma Control Questionnaire (ACQ) score compared with noncomplete responders (Δ 210 versus 30 mL; p<0.0001 and Δ −1.04 versus −0.68; p=0.016, respectively). A complete response was predicted by age at onset, less severe disease at baseline (i.e. no mOCS and lower ACQ score) and higher blood eosinophils.Conclusions More than half of Danish patients treated with anti-IL-5 biologics for severe asthma achieve a complete response to treatment, thereby becoming free from asthma exacerbations and the need for mOCS. Complete responders also achieved superior effects on lung function and symptoms compared with noncomplete responders.More than half of all Danish patients with severe asthma receiving anti-IL-5 in a real-life setting achieve a complete response to treatment, i.e. they become free from exacerbations and the need for oral corticosteroids https://bit.ly/3zMMB75