RT Journal Article
SR Electronic
T1 Associations of influenza vaccination with severity of immune-related adverse events in patients with advanced thoracic cancers on immune checkpoint inhibitors
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00684-2021
DO 10.1183/23120541.00684-2021
VO 8
IS 4
A1 Emily Pei-Ying Lin
A1 Li-Ching Huang
A1 Jennifer Whisenant
A1 Sally York
A1 Travis Osterman
A1 Jennifer Lewis
A1 Wade Iams
A1 Emily Skotte
A1 Amanda Cass
A1 Chih-Yuan Hsu
A1 Yu Shyr
A1 Leora Horn
YR 2022
UL http://openres.ersjournals.com/content/8/4/00684-2021.abstract
AB Background Whether influenza vaccination (FV) is associated with the severity of immune-related adverse events (IRAEs) in patients with advanced thoracic cancer on immune checkpoint inhibitors (ICIs) is not fully understood.Methods Patients enrolled in this retrospective cohort study were identified from the Vanderbilt BioVU database and their medical records were reviewed. Patients with advanced thoracic cancer who received FV within 3 months prior to or during their ICI treatment period were enrolled in the FV-positive cohort and those who did not were enrolled in the FV-negative cohort. The primary objective was to detect whether FV is associated with decreased IRAE severity. The secondary objectives were to evaluate whether FV is associated with a decreased risk for grade 3–5 IRAEs and better survival times. Multivariable ordinal logistic regression was used for the primary analysis.Results A total of 142 and 105 patients were enrolled in the FV-positive and FV-negative cohorts, respectively. There was no statistically significant difference in patient demographics or cumulative incidences of IRAEs between the two cohorts. In the primary analysis, FV was inversely associated with the severity of IRAEs (OR 0.63; p=0.046). In the secondary analysis, FV was associated with a decreased risk for grade 3–5 IRAEs (OR 0.42; p=0.005). Multivariable Cox regression showed that FV was not associated with survival times.Conclusions Our study showed that FV does not increase toxicity for patients with advanced thoracic cancer on ICIs and is associated with a decreased risk for grade 3–5 IRAEs. No statistically significant survival differences were found between patients with and without FV.Influenza vaccination does not increase toxicity for thoracic cancer patients on immune checkpoint inhibitors, but is associated with a decreased risk of severe immune-related adverse events and could be encouraged, especially in the #COVID19 pandemic https://bit.ly/3bw1z7u