TY - JOUR T1 - Validation of the cough phenotype TBQ among elderly Finnish subjects JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00284-2022 VL - 8 IS - 4 SP - 00284-2022 AU - Heikki O. Koskela AU - Johanna T. Kaulamo AU - Tuomas A. Selander AU - Anne M. Lätti Y1 - 2022/10/01 UR - http://openres.ersjournals.com/content/8/4/00284-2022.abstract N2 - Background Phenotypes can be utilised in the clinical management of disorders. Approaches to phenotype disorders have evolved from subjective expert opinion to data-driven methodologies. A previous cluster analysis among working-age subjects with cough revealed a phenotype TBQ (triggers, background disorders, quality-of-life impairment), which included 38% of the subjects with cough. The present study was carried out to validate this phenotyping among elderly, retired subjects with cough.Methods This was an observational cross-sectional study conducted via email among the members of the Finnish Pensioners’ Federation (n=26 205, 23.6% responded). The analysis included 1109 subjects with current cough (mean±sd age 72.9±5.3 years; 67.7% female). All filled in a comprehensive 86-item questionnaire including the Leicester Cough Questionnaire. Phenotypes were identified utilising k-means partitional clustering.Results Two clusters were identified. Cluster A included 75.2% of the subjects and cluster B 24.8% of the subjects. The three most important variables to separate the clusters were the number of cough triggers (mean±sd 2.47±2.34 versus 7.08±3.16, respectively; p<0.001), Leicester Cough Questionnaire physical domain (5.38±0.68 versus 4.21±0.81, respectively; p<0.001) and the number of cough background disorders (0.82±0.78 versus 1.99±0.89 respectively; p<0.001).Conclusion The phenotype TBQ could be identified also among elderly, retired subjects with cough, thus validating the previous phenotyping among working-age subjects. The main underlying pathophysiological feature separating the phenotype TBQ from the common cough phenotype is probably hypersensitivity of the cough reflex arc.The previously described cough phenotype TBQ (triggers, background disorders, quality-of-life impairment) and the common cough phenotype can be identified in elderly, retired subjects with current cough https://bit.ly/3cygezO ER -