RT Journal Article
SR Electronic
T1 Neighbourhood disadvantage impacts on pulmonary function in patients with sarcoidosis
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00357-2022
DO 10.1183/23120541.00357-2022
VO 8
IS 4
A1 Gillian C. Goobie
A1 Christopher J. Ryerson
A1 Kerri A. Johannson
A1 Spencer Keil
A1 Erin Schikowski
A1 Nasreen Khalil
A1 Veronica Marcoux
A1 Deborah Assayag
A1 Hélène Manganas
A1 Jolene H. Fisher
A1 Martin R.J. Kolb
A1 Xiaoping Chen
A1 Kevin F. Gibson
A1 Daniel J. Kass
A1 Yingze Zhang
A1 Kathleen O. Lindell
A1 S. Mehdi Nouraie
YR 2022
UL http://openres.ersjournals.com/content/8/4/00357-2022.abstract
AB Background This multicentre, international, prospective cohort study evaluated whether patients with pulmonary sarcoidosis living in neighbourhoods with greater material and social disadvantage experience worse clinical outcomes.Methods The area deprivation index and the Canadian Index of Multiple Deprivation evaluate neighbourhood-level disadvantage in the US and Canada, with higher scores reflecting greater disadvantage. Multivariable linear regression evaluated associations of disadvantage with baseline forced vital capacity (FVC) or diffusing capacity of the lung for carbon monoxide (DLCO) and linear mixed effects models for associations with rate of FVC or DLCO decline, and competing hazards models were used for survival analyses in the US cohort, evaluating competing outcomes of death or lung transplantation. Adjustments were made for age at diagnosis, sex, race and smoking history.Results We included 477 US and 122 Canadian patients with sarcoidosis. Higher disadvantage was not associated with survival or baseline FVC. The highest disadvantage quartile was associated with lower baseline DLCO in the US cohort (β = −6.80, 95% CI −13.16 to −0.44, p=0.04), with similar findings in the Canadian cohort (β = −7.47, 95% CI −20.28 to 5.33, p=0.25); with more rapid decline in FVC and DLCO in the US cohort (FVC β = −0.40, 95% CI −0.70 to −0.11, p=0.007; DLCO β = −0.59, 95% CI −0.95 to −0.23, p=0.001); and with more rapid FVC decline in the Canadian cohort (FVC β = −0.80, 95% CI −1.37 to −0.24, p=0.003).Conclusion Patients with sarcoidosis living in high disadvantage neighbourhoods experience worse baseline lung function and more rapid lung function decline, highlighting the need for better understanding of how neighbourhood-level factors impact individual patient outcomes.Greater neighbourhood disadvantage is associated with worse baseline lung function and more rapid lung function decline in patients with sarcoidosis in both US and Canadian cohorts, highlighting the impact of socioeconomic disparities in this population https://bit.ly/3R8gUuc