TY - JOUR T1 - Infant lung function and maternal physical activity in the first half of pregnancy JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00172-2022 VL - 8 IS - 4 SP - 00172-2022 AU - Hrefna Katrín Gudmundsdóttir AU - Oda C.L. Carlsen AU - Karen Eline Stensby Bains AU - Martin Färdig AU - Guttorm Haugen AU - Christine M. Jonassen AU - Marissa LeBlanc AU - Björn Nordlund AU - Eva Maria Rehbinder AU - Håvard O. Skjerven AU - Anne Cathrine Staff AU - Riyas Vettukattil AU - Karin C. Lødrup Carlsen Y1 - 2022/10/01 UR - http://openres.ersjournals.com/content/8/4/00172-2022.abstract N2 - Background and aim Physical activity (PA) in pregnancy is important for maternal and possibly offspring health. To study the early origins of lung function we aimed to determine whether PA in the first half of pregnancy is associated with lung function in healthy 3-month-old infants.Methods From the general population-based Preventing Atopic Dermatitis and Allergies in Children birth cohort recruiting infants antenatally in Norway and Sweden, all 812 infants (48.8% girls) with available tidal flow–volume measures in the awake state at 3 months of age and mid-pregnancy data on PA were included. PA was self-reported by the mothers and, based on intensity, we categorised them as active or inactive during pregnancy. Furthermore, we defined active mothers as fairly or highly active. The main outcome was a ratio of time to peak tidal expiratory flow to expiratory time (tPTEF/tE) <0.25. Associations were analysed by logistic regression, adjusting for maternal age, education, parity, pre-pregnancy body mass index, in utero nicotine exposure and parental atopy.Results The mean±sd tPTEF/tE was 0.391±0.08 and did not differ significantly according to maternal PA level in pregnancy. The 290 infants of inactive mothers had higher odds of having tPTEF/tE <0.25 compared to infants of all active mothers (OR 2.07, 95% CI 1.13–3.82; p=0.019) and compared to infants (n=224) of fairly active (OR 2.83, 95% CI 1.26–7.24; p=0.018) but not highly active mothers (n=298).Conclusion Based on self-reported maternal PA in the first half of pregnancy, 3-month-old infants of inactive compared to active mothers had higher odds of a low tPTEF/tE.There is an association between self-reported maternal physical activity in the first half of pregnancy and lung function in healthy 3-month-old infants, with higher odds of low lung function among infants of inactive compared to active mothers https://bit.ly/3BVVv39 ER -