TY - JOUR T1 - Diffuse panniculitis in a teen male with ZZ alpha<sub>1</sub>-antitrypsin deficiency JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00546-2022 SP - 00546-2022 AU - Spyros A. Papiris AU - Anthimos Parmaxidis AU - Sofia Theotokoglou AU - Zoe Tsakiraki AU - Martina Veith AU - Aikaterini Panagiotou AU - Vasiliki Pappa AU - Maria Kallieri AU - Jean-François Mornex AU - Alexander C. Katoulis AU - Dionysios Haritos AU - Ioannis G. Panayiotides AU - Effrosyni D. Manali Y1 - 2023/01/01 UR - http://openres.ersjournals.com/content/early/2022/11/24/23120541.00546-2022.abstract N2 - Diffuse panniculitis is an inflammatory condition of the subcutaneous fat associated with a multiplicity of etiologic factors and nosologic conditions [1, 2]. Diffuse panniculitis commonly occurs spontaneously and presents with painful skin nodules occasionally evolving in skin ulcerating lesions discharging oily yellow exudate. Histology shows an inflammatory infiltrate with lobular, septal, or combined distribution, depending on the subjacent entity and the timing of biopsy, consisting of neutrophils, lymphocytes, histiocytes or a combination thereof; moreover, foamy macrophages, multinuclear giant cells, granulomas, necrosis or vasculitis may be seen [3]. Lesions may heal spontaneously (albeit less commonly) or after appropriate treatment with atrophic scarring. Any part of the superficial body may be involved although upper and lower extremities are more commonly affected [3]. Occasionally it presents as part of a systemic inflammatory syndrome involving several extra-skin tissues and organs and associates with thrombosis, a life-threatening clinical scenario [2].FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article. ER -