TY - JOUR T1 - Modifiable lifestyle risk factors for sarcoidosis: a nested case-control study JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00492-2022 SP - 00492-2022 AU - Marina Dehara AU - Michael C. Sachs AU - Johan Grunewald AU - Anders Blomberg AU - Elizabeth V. Arkema Y1 - 2023/01/01 UR - http://openres.ersjournals.com/content/early/2023/01/05/23120541.00492-2022.abstract N2 - We aimed to investigate whether obesity, tobacco use, alcohol consumption, and physical inactivity are associated with sarcoidosis risk. We conducted a matched case-control study nested within the Northern Sweden Health and Disease Study. Incident sarcoidosis cases (n=165) were identified via medical records and matched to controls (n=660) on sub-cohort, sex, birth, and questionnaire date (1:4). Data on lifestyle factors were obtained through questionnaires, and physical measurements of height, weight and waist were collected prior to sarcoidosis diagnosis. Conditional logistic regression estimated adjusted odds ratios with 95% confidence intervals (aOR; 95%CI). Compared with never smoking, current smoking was associated with lower sarcoidosis odds (aOR 0.48; 95%CI 0.32–0.71), and former smoking with higher odds (aOR 1.33; 95%CI 0.98–1.81). Snus use was not associated with sarcoidosis. There was an increased odds of sarcoidosis associated with obesity (aOR 1.34 (95%CI 0.94–1.92) but not with overweight (aOR 0.99; 95%CI 0.76–1.30). Compared with those who were physically inactive, those who were active had a 25% higher odds (aOR 1.25; 95%CI 0.91–1.72). No association was found with moderate alcohol consumption (aOR 0.95; 95%CI 0.56–1.62). All results were similar when cases diagnosed within 5 years after exposure assessment were excluded, except the aOR for former smoking decreased to 1.1. We observed a reduced sarcoidosis risk associated with smoking, which cannot be fully explained by early symptoms of sarcoidosis influencing smoking habits. Results indicate an increased risk associated with obesity, but not overweight, and being physically active.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: All authors declare that they have no conflict of interest to disclose. ER -