TY - JOUR T1 - Iron mobilization pattern in airway epithelium: tipping the immune balance in asthma JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00475-2022 SP - 00475-2022 AU - Jintao Zhang AU - Ziting Liang AU - Dong Zhang AU - Yun Pan AU - Xiaofei Liu AU - Rong Zeng AU - Wenjing Cui AU - Liang Dong Y1 - 2023/01/01 UR - http://openres.ersjournals.com/content/early/2023/01/05/23120541.00475-2022.abstract N2 - The barrier functions of the airway epithelium are centrally involved in regulating tissue homeostasis in the lung, and abnormal responses of the airway epithelium to the environment, including metal exposure, underlies the rise in allergic conditions and chronic airway diseases [1, 2]. Notably, injury-induced epithelial cell apoptosis and injury with resultant lack of normal restitution of epithelial barriers are increasingly recognised as critical events in the pathogenesis of airway diseases such as asthma [1, 3]. Evidence accumulated in recent years points to a connection between iron regulation and asthma pathogenesis [4, 5]. However, the role of iron in asthmatic airway epithelium remains incompletely understood.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: The authors declare that they have no competing interests. ER -