TY - JOUR T1 - Predictors of invasive mechanical ventilation use in patients with acute decompensated pulmonary hypertension admitted to Intensive Care Unit JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00598-2022 SP - 00598-2022 AU - Marcos V. F. Garcia AU - Rogerio Souza AU - Pedro Caruso Y1 - 2023/01/01 UR - http://openres.ersjournals.com/content/early/2023/02/02/23120541.00598-2022.abstract N2 - In acute decompensated PH (ADPH) patients, invasive mechanical ventilation (IMV) use remains challenging because it has deleterious hemodynamic effects on the right ventricle (RV), which can result in hemodynamic collapse and cardiac arrest [1, 2]. IMV may decrease RV function by reducing RV preload and raising the pulmonary vascular resistance and RV afterload, both decreasing cardiac output. When the compensatory mechanisms are exhausted, ventricle-arterial uncoupling occurs with drop in cardiac index and pulmonary pressures, as well as a rise in central venous pressure, late markers of RV failure and imminent cardiovascular demise [3]. Therefore, unless absolutely required, endotracheal intubation and IMV are strongly advised against [4, 5].FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of interest: Nothing to disclose. ER -