TY - JOUR T1 - Characteristics and risk factors for post-COVID-19 breathlessness after hospitalisation for COVID-19 JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00274-2022 VL - 9 IS - 1 SP - 00274-2022 AU - Luke Daines AU - Bang Zheng AU - Omer Elneima AU - Ewen Harrison AU - Nazir I. Lone AU - John R. Hurst AU - Jeremy S. Brown AU - Elizabeth Sapey AU - James D. Chalmers AU - Jennifer K. Quint AU - Paul Pfeffer AU - Salman Siddiqui AU - Samantha Walker AU - Krisnah Poinasamy AU - Hamish McAuley AU - Marco Sereno AU - Aarti Shikotra AU - Amisha Singapuri AU - Annemarie B. Docherty AU - Michael Marks AU - Mark Toshner AU - Luke S. Howard AU - Alex Horsley AU - Gisli Jenkins AU - Joanna C. Porter AU - Ling-Pei Ho AU - Betty Raman AU - Louise V. Wain AU - Christopher E. Brightling AU - Rachael A. Evans AU - Liam G. Heaney AU - Anthony De Soyza AU - Aziz Sheikh A2 - , Y1 - 2023/01/01 UR - http://openres.ersjournals.com/content/9/1/00274-2022.abstract N2 - Background Persistence of respiratory symptoms, particularly breathlessness, after acute coronavirus disease 2019 (COVID-19) infection has emerged as a significant clinical problem. We aimed to characterise and identify risk factors for patients with persistent breathlessness following COVID-19 hospitalisation.Methods PHOSP-COVID is a multicentre prospective cohort study of UK adults hospitalised for COVID-19. Clinical data were collected during hospitalisation and at a follow-up visit. Breathlessness was measured by a numeric rating scale of 0–10. We defined post-COVID-19 breathlessness as an increase in score of ≥1 compared to the pre-COVID-19 level. Multivariable logistic regression was used to identify risk factors and to develop a prediction model for post-COVID-19 breathlessness.Results We included 1226 participants (37% female, median age 59 years, 22% mechanically ventilated). At a median 5 months after discharge, 50% reported post-COVID-19 breathlessness. Risk factors for post-COVID-19 breathlessness were socioeconomic deprivation (adjusted OR 1.67, 95% CI 1.14–2.44), pre-existing depression/anxiety (adjusted OR 1.58, 95% CI 1.06–2.35), female sex (adjusted OR 1.56, 95% CI 1.21–2.00) and admission duration (adjusted OR 1.01, 95% CI 1.00–1.02). Black ethnicity (adjusted OR 0.56, 95% CI 0.35–0.89) and older age groups (adjusted OR 0.31, 95% CI 0.14–0.66) were less likely to report post-COVID-19 breathlessness. Post-COVID-19 breathlessness was associated with worse performance on the shuttle walk test and forced vital capacity, but not with obstructive airflow limitation. The prediction model had fair discrimination (concordance statistic 0.66, 95% CI 0.63–0.69) and good calibration (calibration slope 1.00, 95% CI 0.80–1.21).Conclusions Post-COVID-19 breathlessness was commonly reported in this national cohort of patients hospitalised for COVID-19 and is likely to be a multifactorial problem with physical and emotional components.Socioeconomic deprivation, pre-existing depression/anxiety, female sex and longer admission duration were risk factors for persistent breathlessness in patients assessed 5 months after hospitalisation for COVID-19 https://bit.ly/3TnzMq1 ER -