RT Journal Article
SR Electronic
T1 Characteristics and risk factors for post-COVID-19 breathlessness after hospitalisation for COVID-19
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00274-2022
DO 10.1183/23120541.00274-2022
VO 9
IS 1
A1 Luke Daines
A1 Bang Zheng
A1 Omer Elneima
A1 Ewen Harrison
A1 Nazir I. Lone
A1 John R. Hurst
A1 Jeremy S. Brown
A1 Elizabeth Sapey
A1 James D. Chalmers
A1 Jennifer K. Quint
A1 Paul Pfeffer
A1 Salman Siddiqui
A1 Samantha Walker
A1 Krisnah Poinasamy
A1 Hamish McAuley
A1 Marco Sereno
A1 Aarti Shikotra
A1 Amisha Singapuri
A1 Annemarie B. Docherty
A1 Michael Marks
A1 Mark Toshner
A1 Luke S. Howard
A1 Alex Horsley
A1 Gisli Jenkins
A1 Joanna C. Porter
A1 Ling-Pei Ho
A1 Betty Raman
A1 Louise V. Wain
A1 Christopher E. Brightling
A1 Rachael A. Evans
A1 Liam G. Heaney
A1 Anthony De Soyza
A1 Aziz Sheikh
A1 ,
YR 2023
UL http://openres.ersjournals.com/content/9/1/00274-2022.abstract
AB Background Persistence of respiratory symptoms, particularly breathlessness, after acute coronavirus disease 2019 (COVID-19) infection has emerged as a significant clinical problem. We aimed to characterise and identify risk factors for patients with persistent breathlessness following COVID-19 hospitalisation.Methods PHOSP-COVID is a multicentre prospective cohort study of UK adults hospitalised for COVID-19. Clinical data were collected during hospitalisation and at a follow-up visit. Breathlessness was measured by a numeric rating scale of 0–10. We defined post-COVID-19 breathlessness as an increase in score of ≥1 compared to the pre-COVID-19 level. Multivariable logistic regression was used to identify risk factors and to develop a prediction model for post-COVID-19 breathlessness.Results We included 1226 participants (37% female, median age 59 years, 22% mechanically ventilated). At a median 5 months after discharge, 50% reported post-COVID-19 breathlessness. Risk factors for post-COVID-19 breathlessness were socioeconomic deprivation (adjusted OR 1.67, 95% CI 1.14–2.44), pre-existing depression/anxiety (adjusted OR 1.58, 95% CI 1.06–2.35), female sex (adjusted OR 1.56, 95% CI 1.21–2.00) and admission duration (adjusted OR 1.01, 95% CI 1.00–1.02). Black ethnicity (adjusted OR 0.56, 95% CI 0.35–0.89) and older age groups (adjusted OR 0.31, 95% CI 0.14–0.66) were less likely to report post-COVID-19 breathlessness. Post-COVID-19 breathlessness was associated with worse performance on the shuttle walk test and forced vital capacity, but not with obstructive airflow limitation. The prediction model had fair discrimination (concordance statistic 0.66, 95% CI 0.63–0.69) and good calibration (calibration slope 1.00, 95% CI 0.80–1.21).Conclusions Post-COVID-19 breathlessness was commonly reported in this national cohort of patients hospitalised for COVID-19 and is likely to be a multifactorial problem with physical and emotional components.Socioeconomic deprivation, pre-existing depression/anxiety, female sex and longer admission duration were risk factors for persistent breathlessness in patients assessed 5 months after hospitalisation for COVID-19 https://bit.ly/3TnzMq1