TY - JOUR T1 - COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00317-2022 VL - 9 IS - 2 SP - 00317-2022 AU - Sabina Sahanic AU - Piotr Tymoszuk AU - Anna K. Luger AU - Katharina Hüfner AU - Anna Boehm AU - Alex Pizzini AU - Christoph Schwabl AU - Sabine Koppelstätter AU - Katharina Kurz AU - Malte Asshoff AU - Birgit Mosheimer-Feistritzer AU - Maximilian Coen AU - Bernhard Pfeifer AU - Verena Rass AU - Alexander Egger AU - Gregor Hörmann AU - Barbara Sperner-Unterweger AU - Raimund Helbok AU - Ewald Wöll AU - Günter Weiss AU - Gerlig Widmann AU - Ivan Tancevski AU - Thomas Sonnweber AU - Judith Löffler-Ragg Y1 - 2023/03/01 UR - http://openres.ersjournals.com/content/9/2/00317-2022.abstract N2 - Background Recovery trajectories from coronavirus disease 2019 (COVID-19) call for longitudinal investigation. We aimed to characterise the kinetics and status of clinical, cardiopulmonary and mental health recovery up to 1 year following COVID-19.Methods Clinical evaluation, lung function testing (LFT), chest computed tomography (CT) and transthoracic echocardiography were conducted at 2, 3, 6 and 12 months after disease onset. Submaximal exercise capacity, mental health status and quality of life were assessed at 12 months. Recovery kinetics and patterns were investigated by mixed-effect logistic modelling, correlation and clustering analyses. Risk of persistent symptoms and cardiopulmonary abnormalities at the 1-year follow-up were modelled by logistic regression.Findings Out of 145 CovILD study participants, 108 (74.5%) completed the 1-year follow-up (median age 56.5 years; 59.3% male; 24% intensive care unit patients). Comorbidities were present in 75% (n=81). Key outcome measures plateaued after 180 days. At 12 months, persistent symptoms were found in 65% of participants; 33% suffered from LFT impairment; 51% showed CT abnormalities; and 63% had low-grade diastolic dysfunction. Main risk factors for cardiopulmonary impairment included pro-inflammatory and immunological biomarkers at early visits. In addition, we deciphered three recovery clusters separating almost complete recovery from patients with post-acute inflammatory profile and an enrichment in cardiopulmonary residuals from a female-dominated post-COVID-19 syndrome with reduced mental health status.Conclusion 1 year after COVID-19, the burden of persistent symptoms, impaired lung function, radiological abnormalities remains high in our study population. Yet, three recovery trajectories are emerging, ranging from almost complete recovery to post-COVID-19 syndrome with impaired mental health.1 year after #COVID19, 51% show radiological abnormalities and 33% show functional lung impairment. Yet, three recovery trajectories are emerging, ranging from almost complete recovery to post-COVID syndrome with impaired mental health. https://bit.ly/3gYbNQq ER -