RT Journal Article
SR Electronic
T1 Hyperoxia improves exercise capacity in cardiopulmonary disease: a series of randomised controlled trials
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00563-2022
DO 10.1183/23120541.00563-2022
VO 9
IS 2
A1 Julian Müller
A1 Mona Lichtblau
A1 Stéphanie Saxer
A1 Simon R. Schneider
A1 Paula Appenzeller
A1 Meret Bauer
A1 Elisabeth D. Hasler
A1 Esther I. Schwarz
A1 Konrad E. Bloch
A1 Silvia Ulrich
YR 2023
UL http://openres.ersjournals.com/content/9/2/00563-2022.abstract
AB Background The aim of this study was to investigate the overall and differential effect of breathing hyperoxia (inspiratory oxygen fraction (FIO2) 0.5) versus placebo (ambient air, FIO2 0.21) to enhance exercise performance in healthy people, patients with pulmonary vascular disease (PVD) with precapillary pulmonary hypertension (PH), COPD, PH due to heart failure with preserved ejection fraction (HFpEF) and cyanotic congenital heart disease (CHD) using data from five randomised controlled trials performed with identical protocols.Methods 91 subjects (32 healthy, 22 with PVD with pulmonary arterial or distal chronic thromboembolic PH, 20 with COPD, 10 with PH in HFpEF and seven with CHD) performed two cycle incremental (IET) and two constant work-rate exercise tests (CWRET) at 75% of maximal load (Wmax), each with ambient air and hyperoxia in single-blinded, randomised, controlled, crossover trials. The main outcomes were differences in Wmax (IET) and cycling time (CWRET) with hyperoxia versus ambient air.Results Overall, hyperoxia increased Wmax by +12 W (95% CI: 9–16, p<0.001) and cycling time by +6:13 min (4:50–7:35, p<0.001), with improvements being highest in patients with PVD (Wmax/min: +18%/+118% versus COPD: +8%/+60%, healthy: +5%/+44%, HFpEF: +6%/+28%, CHD: +9%/+14%).Conclusion This large sample of healthy subjects and patients with various cardiopulmonary diseases confirms that hyperoxia significantly prolongs cycling exercise with improvements being highest in endurance CWRET and patients with PVD. These results call for studies investigating optimal oxygen levels to prolong exercise time and effects on training.Supplemental oxygen during exercise significantly improves exercise performance in cardiopulmonary disease in terms of maximal work rate as well as endurance time. Largest improvements were found in patients with pulmonary vascular disease. https://bit.ly/3W1i6Ti