TY - JOUR T1 - Cardiovascular disease-linked plasma proteins are mainly associated with lung volume JF - ERJ Open Research JO - erjor DO - 10.1183/23120541.00321-2022 VL - 9 IS - 2 SP - 00321-2022 AU - Andreas Rydell AU - Elisabet Nerpin AU - XingWu Zhou AU - Lars Lind AU - Eva Lindberg AU - Jenny Theorell Haglöw AU - Tove Fall AU - Christer Janson AU - Karin Lisspers AU - Sölve Elmståhl AU - Suneela Zaigham AU - Olle Melander AU - Peter M. Nilsson AU - Johan Ärnlöv AU - Andrei Malinovschi Y1 - 2023/03/01 UR - http://openres.ersjournals.com/content/9/2/00321-2022.abstract N2 - Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio.Methods We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease- and metabolism-linked proteins in relation to FEV1, FVC (both % predicted) and FEV1/FVC ratio. A false discovery rate of 5% was used as the significance threshold in the discovery cohort.Results Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV1 and paraoxonase 3 was positively associated therewith. Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. No proteins were associated with FEV1/FVC ratio. A sensitivity analysis in EpiHealth revealed only minor changes after excluding individuals with known cardiovascular disease, diabetes or obesity.Conclusions Five proteins were associated with both FEV1 and FVC. Four proteins associated with only FVC and none with FEV1/FVC ratio, suggesting associations mainly through lung volume, not airway obstruction. However, additional studies are needed to investigate underlying mechanisms for these findings.Several cardiovascular disease-linked proteins were associated with FEV1 and FVC, but not with FEV1/FVC ratio, suggesting that the relationships are mainly with lung volume, not airflow obstruction https://bit.ly/3j19Io8 ER -