RT Journal Article
SR Electronic
T1 Cardiovascular disease-linked plasma proteins are mainly associated with lung volume
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00321-2022
DO 10.1183/23120541.00321-2022
VO 9
IS 2
A1 Andreas Rydell
A1 Elisabet Nerpin
A1 XingWu Zhou
A1 Lars Lind
A1 Eva Lindberg
A1 Jenny Theorell Haglöw
A1 Tove Fall
A1 Christer Janson
A1 Karin Lisspers
A1 Sölve Elmståhl
A1 Suneela Zaigham
A1 Olle Melander
A1 Peter M. Nilsson
A1 Johan Ärnlöv
A1 Andrei Malinovschi
YR 2023
UL http://openres.ersjournals.com/content/9/2/00321-2022.abstract
AB Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio.Methods We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease- and metabolism-linked proteins in relation to FEV1, FVC (both % predicted) and FEV1/FVC ratio. A false discovery rate of 5% was used as the significance threshold in the discovery cohort.Results Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV1 and paraoxonase 3 was positively associated therewith. Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. No proteins were associated with FEV1/FVC ratio. A sensitivity analysis in EpiHealth revealed only minor changes after excluding individuals with known cardiovascular disease, diabetes or obesity.Conclusions Five proteins were associated with both FEV1 and FVC. Four proteins associated with only FVC and none with FEV1/FVC ratio, suggesting associations mainly through lung volume, not airway obstruction. However, additional studies are needed to investigate underlying mechanisms for these findings.Several cardiovascular disease-linked proteins were associated with FEV1 and FVC, but not with FEV1/FVC ratio, suggesting that the relationships are mainly with lung volume, not airflow obstruction https://bit.ly/3j19Io8