PT  - JOURNAL ARTICLE
AU  - Yin Ting Lam
AU  - Jean-François Papon
AU  - Mihaela Alexandru
AU  - Andreas Anagiotos
AU  - Miguel Armengot
AU  - Mieke Boon
AU  - Andrea Burgess
AU  - Suzanne Crowley
AU  - Sinan Ahmed D. Dheyauldeen
AU  - Nagehan Emiralioglu
AU  - Ela Erdem Eralp
AU  - Christine van Gogh
AU  - Yasemin Gokdemir
AU  - Onder Gunaydın
AU  - Eric G. Haarman
AU  - Amanda Harris
AU  - Isolde Hayn
AU  - Hasnaa Ismail-Koch
AU  - Bülent Karadag
AU  - Céline Kempeneers
AU  - Sookyung Kim
AU  - Philipp Latzin
AU  - Natalie Lorent
AU  - Ugur Ozcelik
AU  - Charlotte Pioch
AU  - Anne-Lise M.L. Poirrier
AU  - Ana Reula
AU  - Jobst Roehmel
AU  - Panayiotis Yiallouros
AU  - on behalf of the EPIC-PCD team
AU  - Myrofora Goutaki
AU  - EPIC-PCD team:
AU  - Dilber Ademhan
AU  - Mihaela Alexandru
AU  - Andreas Anagiotos
AU  - Miguel Armengot
AU  - Lionel Benchimol
AU  - Achim G. Beule
AU  - Irma Bon
AU  - Mieke Boon
AU  - Marina Bullo
AU  - Andrea Burgess
AU  - Doriane Calmes
AU  - Carmen Casaulta
AU  - Marco Caversaccio
AU  - Nathalie Caversaccio
AU  - Bruno Crestani
AU  - Suzanne Crowley
AU  - Sinan Ahmed D. Dheyauldeen
AU  - Sandra Diepenhorst
AU  - Nagehan Emiralioglu
AU  - Ela Erdem Eralp
AU  - Pinar Ergenekon
AU  - Nathalie Feyaerts
AU  - Gavriel Georgiou
AU  - Amy Glen
AU  - Christine van Gogh
AU  - Yasemin Gokdemir
AU  - Myrofora Goutaki
AU  - Onder Gunaydın
AU  - Eric G. Haarman
AU  - Amanda Harris
AU  - Isolde Hayn
AU  - Simone Helms
AU  - Sara-Lynn Hool
AU  - Isabelle Honoré
AU  - Hasnaa Ismail Koch
AU  - Bülent Karadag
AU  - Céline Kempeneers
AU  - Synne Kennelly
AU  - Elisabeth Kieninger
AU  - Sookyung Kim
AU  - Panayiotis Kouis
AU  - Yin Ting Lam
AU  - Philipp Latzin
AU  - Marie Legendre
AU  - Natalie Lorent
AU  - Jane S. Lucas
AU  - Bernard Maitre
AU  - Alison McEvoy
AU  - Rana Mitri-Frangieh
AU  - David Montani
AU  - Loretta Müller
AU  - Noelia Muñoz
AU  - Heymut Omran
AU  - Ugur Ozcelik
AU  - Beste Ozsezen
AU  - Samantha Packham
AU  - Jean-François Papon
AU  - Clara Pauly
AU  - Charlotte Pioch
AU  - Anne-Lise M.L. Poirrier
AU  - Johanna Raidt
AU  - Ana Reula
AU  - Rico Rinkel
AU  - Jobst Roehmel
AU  - Andre Schramm
AU  - Guillaume Thouvenin
AU  - Woolf T Walker
AU  - Hannah Wilkins
AU  - Panayiotis Yiallouros
AU  - Ali Cemal Yumusakhuylu
AU  - Niklas Ziegahn
TI  - Sinonasal disease among patients with primary ciliary dyskinesia: an international study
AID  - 10.1183/23120541.00701-2022
DP  - 2023 May 01
TA  - ERJ Open Research
PG  - 00701-2022
VI  - 9
IP  - 3
4099  - http://openres.ersjournals.com/content/9/3/00701-2022.short
4100  - http://openres.ersjournals.com/content/9/3/00701-2022.full
SO  - erjor2023 May 01; 9
AB  - Background Sinonasal symptoms are a common feature of primary ciliary dyskinesia (PCD); however, literature about their severity and frequency, particularly during the life course, is scarce. Using baseline data from the Ear, nose and throat (ENT) Prospective International Cohort of PCD patients, we describe sinonasal disease in PCD.Methods We included participants who had a routine sinonasal examination during which they completed a symptoms questionnaire. We compared frequency of reported symptoms and examination findings among children and adults, and identified characteristics potentially associated with higher risk of sinonasal disease using ordinal regression.Results 12 centres contributed 384 participants; median age was 16 years (IQR 9–22), and 54% were male. Chronic nasal problems were the most common feature, reported by 341 (89%). More adults (33; 24%) than children (10; 4%) described hyposmia. Quality of life was moderately affected by rhinosinusitis among 136 participants with completed SNOT-22 questionnaires (median score 31; IQR 23–45). Examinations revealed nasal polyps among 51 of 345 participants (15%) and hypertrophic inferior nasal turbinates among 127 of 341 participants (37%). Facial pain was detected in 50 of 342 participants (15%). Nasal polyps, hypertrophic turbinates, deviated septum and facial pain were found more commonly in adults than children. The only characteristic associated with higher risk of sinonasal disease was age 10 years and older.Conclusions Based on our findings, regular sinonasal examinations are relevant for patients with PCD of all ages. There is a need for improved management of sinonasal disease supported by evidence-based guidelines.This study reinforces the importance of regular sinonasal examinations for patients of all ages with PCD and the need to develop evidence-based sinonasal treatments as part of overall PCD management https://bit.ly/3lMcgbo