PT  - JOURNAL ARTICLE
AU  - Lam, Yin Ting
AU  - Papon, Jean-François
AU  - Alexandru, Mihaela
AU  - Anagiotos, Andreas
AU  - Armengot, Miguel
AU  - Boon, Mieke
AU  - Burgess, Andrea
AU  - Crowley, Suzanne
AU  - Dheyauldeen, Sinan Ahmed D.
AU  - Emiralioglu, Nagehan
AU  - Erdem Eralp, Ela
AU  - van Gogh, Christine
AU  - Gokdemir, Yasemin
AU  - Gunaydın, Onder
AU  - Haarman, Eric G.
AU  - Harris, Amanda
AU  - Hayn, Isolde
AU  - Ismail-Koch, Hasnaa
AU  - Karadag, Bülent
AU  - Kempeneers, Céline
AU  - Kim, Sookyung
AU  - Latzin, Philipp
AU  - Lorent, Natalie
AU  - Ozcelik, Ugur
AU  - Pioch, Charlotte
AU  - Poirrier, Anne-Lise M.L.
AU  - Reula, Ana
AU  - Roehmel, Jobst
AU  - Yiallouros, Panayiotis
AU  - ,
AU  - Goutaki, Myrofora
AU  - ,
AU  - Ademhan, Dilber
AU  - Alexandru, Mihaela
AU  - Anagiotos, Andreas
AU  - Armengot, Miguel
AU  - Benchimol, Lionel
AU  - Beule, Achim G.
AU  - Bon, Irma
AU  - Boon, Mieke
AU  - Bullo, Marina
AU  - Burgess, Andrea
AU  - Calmes, Doriane
AU  - Casaulta, Carmen
AU  - Caversaccio, Marco
AU  - Caversaccio, Nathalie
AU  - Crestani, Bruno
AU  - Crowley, Suzanne
AU  - Dheyauldeen, Sinan Ahmed D.
AU  - Diepenhorst, Sandra
AU  - Emiralioglu, Nagehan
AU  - Eralp, Ela Erdem
AU  - Ergenekon, Pinar
AU  - Feyaerts, Nathalie
AU  - Georgiou, Gavriel
AU  - Glen, Amy
AU  - Gogh, Christine van
AU  - Gokdemir, Yasemin
AU  - Goutaki, Myrofora
AU  - Gunaydın, Onder
AU  - Haarman, Eric G.
AU  - Harris, Amanda
AU  - Hayn, Isolde
AU  - Helms, Simone
AU  - Hool, Sara-Lynn
AU  - Honoré, Isabelle
AU  - Ismail Koch, Hasnaa
AU  - Karadag, Bülent
AU  - Kempeneers, Céline
AU  - Kennelly, Synne
AU  - Kieninger, Elisabeth
AU  - Kim, Sookyung
AU  - Kouis, Panayiotis
AU  - Lam, Yin Ting
AU  - Latzin, Philipp
AU  - Legendre, Marie
AU  - Lorent, Natalie
AU  - Lucas, Jane S.
AU  - Maitre, Bernard
AU  - McEvoy, Alison
AU  - Mitri-Frangieh, Rana
AU  - Montani, David
AU  - Müller, Loretta
AU  - Muñoz, Noelia
AU  - Omran, Heymut
AU  - Ozcelik, Ugur
AU  - Ozsezen, Beste
AU  - Packham, Samantha
AU  - Papon, Jean-François
AU  - Pauly, Clara
AU  - Pioch, Charlotte
AU  - Poirrier, Anne-Lise M.L.
AU  - Raidt, Johanna
AU  - Reula, Ana
AU  - Rinkel, Rico
AU  - Roehmel, Jobst
AU  - Schramm, Andre
AU  - Thouvenin, Guillaume
AU  - Walker, Woolf T
AU  - Wilkins, Hannah
AU  - Yiallouros, Panayiotis
AU  - Yumusakhuylu, Ali Cemal
AU  - Ziegahn, Niklas
TI  - Sinonasal disease among patients with primary ciliary dyskinesia: an international study
AID  - 10.1183/23120541.00701-2022
DP  - 2023 May 01
TA  - ERJ Open Research
PG  - 00701-2022
VI  - 9
IP  - 3
4099  - http://openres.ersjournals.com/content/9/3/00701-2022.short
4100  - http://openres.ersjournals.com/content/9/3/00701-2022.full
SO  - erjor2023 May 01; 9
AB  - Background Sinonasal symptoms are a common feature of primary ciliary dyskinesia (PCD); however, literature about their severity and frequency, particularly during the life course, is scarce. Using baseline data from the Ear, nose and throat (ENT) Prospective International Cohort of PCD patients, we describe sinonasal disease in PCD.Methods We included participants who had a routine sinonasal examination during which they completed a symptoms questionnaire. We compared frequency of reported symptoms and examination findings among children and adults, and identified characteristics potentially associated with higher risk of sinonasal disease using ordinal regression.Results 12 centres contributed 384 participants; median age was 16 years (IQR 9–22), and 54% were male. Chronic nasal problems were the most common feature, reported by 341 (89%). More adults (33; 24%) than children (10; 4%) described hyposmia. Quality of life was moderately affected by rhinosinusitis among 136 participants with completed SNOT-22 questionnaires (median score 31; IQR 23–45). Examinations revealed nasal polyps among 51 of 345 participants (15%) and hypertrophic inferior nasal turbinates among 127 of 341 participants (37%). Facial pain was detected in 50 of 342 participants (15%). Nasal polyps, hypertrophic turbinates, deviated septum and facial pain were found more commonly in adults than children. The only characteristic associated with higher risk of sinonasal disease was age 10 years and older.Conclusions Based on our findings, regular sinonasal examinations are relevant for patients with PCD of all ages. There is a need for improved management of sinonasal disease supported by evidence-based guidelines.This study reinforces the importance of regular sinonasal examinations for patients of all ages with PCD and the need to develop evidence-based sinonasal treatments as part of overall PCD management https://bit.ly/3lMcgbo