RT Journal Article
SR Electronic
T1 Sinonasal disease among patients with primary ciliary dyskinesia: an international study
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00701-2022
DO 10.1183/23120541.00701-2022
VO 9
IS 3
A1 Lam, Yin Ting
A1 Papon, Jean-François
A1 Alexandru, Mihaela
A1 Anagiotos, Andreas
A1 Armengot, Miguel
A1 Boon, Mieke
A1 Burgess, Andrea
A1 Crowley, Suzanne
A1 Dheyauldeen, Sinan Ahmed D.
A1 Emiralioglu, Nagehan
A1 Erdem Eralp, Ela
A1 van Gogh, Christine
A1 Gokdemir, Yasemin
A1 Gunaydın, Onder
A1 Haarman, Eric G.
A1 Harris, Amanda
A1 Hayn, Isolde
A1 Ismail-Koch, Hasnaa
A1 Karadag, Bülent
A1 Kempeneers, Céline
A1 Kim, Sookyung
A1 Latzin, Philipp
A1 Lorent, Natalie
A1 Ozcelik, Ugur
A1 Pioch, Charlotte
A1 Poirrier, Anne-Lise M.L.
A1 Reula, Ana
A1 Roehmel, Jobst
A1 Yiallouros, Panayiotis
A1 on behalf of the EPIC-PCD team
A1 Goutaki, Myrofora
A1 EPIC-PCD team:
A1 Ademhan, Dilber
A1 Alexandru, Mihaela
A1 Anagiotos, Andreas
A1 Armengot, Miguel
A1 Benchimol, Lionel
A1 Beule, Achim G.
A1 Bon, Irma
A1 Boon, Mieke
A1 Bullo, Marina
A1 Burgess, Andrea
A1 Calmes, Doriane
A1 Casaulta, Carmen
A1 Caversaccio, Marco
A1 Caversaccio, Nathalie
A1 Crestani, Bruno
A1 Crowley, Suzanne
A1 Dheyauldeen, Sinan Ahmed D.
A1 Diepenhorst, Sandra
A1 Emiralioglu, Nagehan
A1 Eralp, Ela Erdem
A1 Ergenekon, Pinar
A1 Feyaerts, Nathalie
A1 Georgiou, Gavriel
A1 Glen, Amy
A1 Gogh, Christine van
A1 Gokdemir, Yasemin
A1 Goutaki, Myrofora
A1 Gunaydın, Onder
A1 Haarman, Eric G.
A1 Harris, Amanda
A1 Hayn, Isolde
A1 Helms, Simone
A1 Hool, Sara-Lynn
A1 Honoré, Isabelle
A1 Ismail Koch, Hasnaa
A1 Karadag, Bülent
A1 Kempeneers, Céline
A1 Kennelly, Synne
A1 Kieninger, Elisabeth
A1 Kim, Sookyung
A1 Kouis, Panayiotis
A1 Lam, Yin Ting
A1 Latzin, Philipp
A1 Legendre, Marie
A1 Lorent, Natalie
A1 Lucas, Jane S.
A1 Maitre, Bernard
A1 McEvoy, Alison
A1 Mitri-Frangieh, Rana
A1 Montani, David
A1 Müller, Loretta
A1 Muñoz, Noelia
A1 Omran, Heymut
A1 Ozcelik, Ugur
A1 Ozsezen, Beste
A1 Packham, Samantha
A1 Papon, Jean-François
A1 Pauly, Clara
A1 Pioch, Charlotte
A1 Poirrier, Anne-Lise M.L.
A1 Raidt, Johanna
A1 Reula, Ana
A1 Rinkel, Rico
A1 Roehmel, Jobst
A1 Schramm, Andre
A1 Thouvenin, Guillaume
A1 Walker, Woolf T
A1 Wilkins, Hannah
A1 Yiallouros, Panayiotis
A1 Yumusakhuylu, Ali Cemal
A1 Ziegahn, Niklas
YR 2023
UL https://publications.ersnet.org//content/9/3/00701-2022.abstract
AB Background Sinonasal symptoms are a common feature of primary ciliary dyskinesia (PCD); however, literature about their severity and frequency, particularly during the life course, is scarce. Using baseline data from the Ear, nose and throat (ENT) Prospective International Cohort of PCD patients, we describe sinonasal disease in PCD.Methods We included participants who had a routine sinonasal examination during which they completed a symptoms questionnaire. We compared frequency of reported symptoms and examination findings among children and adults, and identified characteristics potentially associated with higher risk of sinonasal disease using ordinal regression.Results 12 centres contributed 384 participants; median age was 16 years (IQR 9–22), and 54% were male. Chronic nasal problems were the most common feature, reported by 341 (89%). More adults (33; 24%) than children (10; 4%) described hyposmia. Quality of life was moderately affected by rhinosinusitis among 136 participants with completed SNOT-22 questionnaires (median score 31; IQR 23–45). Examinations revealed nasal polyps among 51 of 345 participants (15%) and hypertrophic inferior nasal turbinates among 127 of 341 participants (37%). Facial pain was detected in 50 of 342 participants (15%). Nasal polyps, hypertrophic turbinates, deviated septum and facial pain were found more commonly in adults than children. The only characteristic associated with higher risk of sinonasal disease was age 10 years and older.Conclusions Based on our findings, regular sinonasal examinations are relevant for patients with PCD of all ages. There is a need for improved management of sinonasal disease supported by evidence-based guidelines.This study reinforces the importance of regular sinonasal examinations for patients of all ages with PCD and the need to develop evidence-based sinonasal treatments as part of overall PCD management https://bit.ly/3lMcgbo