RT Journal Article
SR Electronic
T1 Safety, Feasibility and Effectiveness of the remotely delivered <em>P</em>ulmonary <em>H</em>ypertension <em>A</em>nd <em>H</em>ome-<em>B</em>ased (PHAHB) Physical Activity intervention
JF ERJ Open Research
JO erjor
FD European Respiratory Society
SP 00608-2023
DO 10.1183/23120541.00608-2023
A1 McCormack, Ciara
A1 Kehoe, Brona
A1 Cullivan, Sarah
A1 McCaffrey, Noel
A1 Gaine, Sean
A1 McCullagh, Brian
A1 McCarren, Andrew
A1 Hardcastle, Sarah J.
A1 Moyna, Niall M.
YR 2023
UL https://publications.ersnet.org//content/early/2023/10/12/23120541.00608-2023.abstract
AB Background Pulmonary hypertension (PH) is a heterogeneous condition, associated with a high symptom burden and a substantial loss of exercise capacity. Despite prior safety concerns regarding physical exertion, exercise training as a supportive therapy is now recommended for PH patients. Currently, most programs are hospital-based, which limits accessibility. There is a need to provide alternative approaches for physical activity engagement for PH patients. The aim of this research was to develop, implement and evaluate the safety, feasibility, and effectiveness of home-based physical activity intervention for PH.Methods An entirely remotely delivered home-based exercise intervention underpinned by behaviour change theory and informed by end-users, was assessed using a single-arm feasibility study design. Participants (n=19; 80% female) with a mean (±sd) age of 49.9±15.9 y with a diagnosis of PH undertook a 10-week, home-based exercise intervention with induction training, support materials, telecommunication support, health coaching, exercise training, and assessments, all remotely delivered. Training involved respiratory training along with a combination of aerobic and resistance exercises.Results The intervention was deemed safe as no adverse events were reported. A high level of feasibility was demonstrated as the protocol was implemented as intended, sustained a high level of engagement and adherence and was well accepted by participants in terms of enjoyment and utility. There was a significant improvement in functional capacity, physical activity, exercise self-efficacy and quality of life (QoL), between baseline and post-training.Conclusion The study demonstrates that an entirely remotely delivered home-based exercise program is safe, feasible and effective in improving functional capacity, physical activity, and QoL in PH patients.FootnotesThis manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article.Conflict of Interest: B. Kehoe institution has received grant funding for the submitted research from Actelion Pharmaceuticals; received grant funding from National Cancer Control Programme and Irish Research Council, outside of the work submitted.Conflict of Interest: N. Moyna institution has received grant funding for the submitted research from Actelion Pharmaceuticals; received grants from Enterprise Ireland and Health Service Executive, outside of the submitted work; received consulting fees from Irish Health Life, outside of the submitted work.Conflict of Interest: B. McCullagh has received honoraria and speaker's fees from Janssen Pharmaceuticals, outside the submitted work; and received travel support from Janssen Pharmaceuticals, outside the submitted work.Conflict of Interest: S. Gaine institution has received grant funding for the submitted research from Actelion Pharmaceuticals; received honoraria and speaker's fees from MSD and Janssen Pharmaceuticals, outside the submitted work; received travel support from MSD and Janssen Pharmaceuticals, outside the submitted work; participated in a DSMB for United Therapeutics and Janssen Pharmaceuticals; and has received consulting fees from or Altavant, Gossamer Bio, Janseen and MSD outside the submitted work.Conflict of Interest: All other authors have nothing to disclose.