TABLE 4

Reclassification analysis from biomarkers related to pulmonary arterial hypertension in multivariable-adjusted models

Biomarker added to the composite treatment and prognosis goals#NRI (95% CI)IDI (95% CI)
CategoricalContinuous
ProANP0.3235 (0.1285–0.5185) (p=0.00115)0.6993 (−0.0045–1.403) (p=0.05149)0.1262 (−0.0343–0.2867) (p=0.1233)
hsTnT0.2571 (0.0921–0.4222) (p=0.00226)0.7683 (0.0726–1.464) (p=0.03042)0.1429 (−0.0496–0.3354) (p=0.1456)
GDF-150.1143 (−0.0395–0.2681) (p=0.1453)0.654 (−0.0524–1.36) (p=0.06959)0.0814 (−0.0829–0.2457) (p=0.3315)
sFlt-1−0.0286 (−0.0838–0.0266) (p=0.3103)0.3683 (−0.3557–1.092) (p=0.3187)6e−04 (−0.0054–0.0065) (p=0.8554)
PlGF−0.0286 (−0.0838–0.0266) (p=0.3103)0.3048 (−0.3946–1.004) (p=0.393)0.0137 (−0.0083–0.0356) (p=0.2226)
ProANP+hsTnT0.2941 (0.1206–0.4676) (p=0.00089)0.817 (0.1254–1.509) (p=0.02059)0.1582 (−0.0338–0.3502) (p=0.1064)
ProANP+GDF-150.2647 (0.0769–0.4525) (p=0.00574)0.7582 (0.0601–1.456) (p=0.03327)0.1312 (−0.0393–0.3018) (p=0.1315)
hsTnT+GDF-150.2 (0.0265–0.3735) (p=0.02387)0.7111 (0.0098−1.412) (p=0.04688)0.1482 (−0.044–0.3403) (p=0.1307)
ProANP+sFlt-10.3529 (0.1552–0.5507) (p=0.00047)0.6405 (−0.0686–1.35) (p=0.07667)0.1264 (−0.0339–0.2867) (p=0.1222)
hsTnT+sFlt-10.2857 (0.0988–0.4726) (p=0.00274)0.8825 (0.1999−1.565) (p=0.01128)0.1474 (−0.0453–0.3401) (p=0.1338)
ProANP+PlGF0.2941 (0.1024–0.4858) (p=0.00264)0.4641 (−0.2574–1.185) (p=0.2074)0.1545 (−0.0132–0.3221) (p=0.07091)
hsTnT+PlGF0.2857 (0.1164–0.455) (p=0.00094)0.4825 (−0.2359–1.201) (p=0.188)0.1588 (−0.0352–0.3529) (p=0.1086)
  • Risk categories: low, 0–2%; intermediate, 2–15%; high, ⩾15%. NRI: net reclassification index; IDI: integrated discrimination index; proANP: pro-atrial natriuretic peptide; hsTnT: high-sensitivity troponin T; GDF-15: growth differentiation factor 15; sFlt-1: soluble fms-like tyrosine kinase 1; PlGF: placental growth factor. #: World Health Organization functional class, 6-min walk test, tricuspid annular plane systolic excursion, peak oxygen uptake, N-terminal pro-brain natriuretic peptide and cardiac index. Bold indicates statistical significance.